Health Studies

To Age or Not to Age -- New Movie

2010-09-01T18:47:00.000-07:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

I wonder whether anybody here have seen this new documentary film, to comment on it:

To Age or Not to Age -- the Movie
- documentary film from Robert Kane Pappas

Film Description:

TO AGE OR NOT TO AGE, a new documentary film from Robert Kane Pappas, the director of ORWELL ROLLS IN HIS GRAVE. Imagine a 120 year old as healthy and active as a 50 year old. Is it possible? According to Robert Kane Pappas' riveting new film, TO AGE OR NOT TO AGE, this is both possible and imminent. Since 2006 he has tracked the pioneers in the field of aging research at MIT, Harvard, Cambridge and other research centers. Scientists featured in the film has identified regulator genes that control the aging process; what's more, they have found that aging and disease are so closely related molecularly, that if you delay aging you delay and mitigate all the major diseases. A side effect is increased lifespan. That this can be done no longer seems in doubt. The real question now is "How soon" and "for how long"? The stunning paradigm shift is that aging and death are not the absolutes we once thought they were, some scientists think we will be able to reverse aging soon. Aubrey de Grey believes we will end aging as a cause of death.

TO AGE OR NOT TO AGE, ponder the repercussions of such profound conceptual change - the psychological, ethical, religious and economic implications of increased lifespan. Who will access to these medicines? Who will benefit from the breakthroughs? What about political power, population issues? Besides making the science itself understandable to the average viewer, Mr. Pappas' film gives a sense of who these scientists are, including MIT's Dr. Leonard Guarente, Dr. Cynthia Kenyon from UCSF, and major biotech entrepreneurs like Christoph Wesphal and his partner, David Sinclair of Harvard, who identified resveratrol, a substance found in the skin of grapes. But the story is bigger than a single compound or breakthrough, if is a watershed in our understanding of the human condition. 20 years ago there were 3 or 4 labs studying aging. Now there are several hundred worldwide. TO AGE OR NOT TO AGE? - that is the question.

Key words:
To Age or Not to Age, Movie, Robert Kane Pappas, Aubrey de Grey, Leonard Guarente, Cynthia Kenyon, Christoph Wesphal, David Sinclair, resveratrol, documentary film.

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Russian Studies

2010-01-03T20:54:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

This page summarizes our studies on health, mortality and lifespan in Russia and the former Soviet Union.

Publications with weblinks to the full text are listed in a reversed chronological order -- most recent articles go first. The list of papers starts with publications in English, then the articles in Russian follow with English abstracts provided:

Gavrilova, N.S., Gavrilov, L.A., Semyonova, V.G., Evdokushkina, G.N., Ivanova, A.E. 2005. Patterns of violent crime in Russia. In: Pridemore, W.A. (ed.). Ruling Russia: Law, Crime, and Justice in a Changing Society. Boulder, CO: Rowman & Littlefield Publ., Inc, 117-145
To download full text click here

Gavrilova, N.S., Semyonova, V.G., Evdokushkina G.N., Gavrilov, L.A. The response of violent mortality to economic crisis in Russia. Population Research and Policy Review, 2000, 19: 397-419.
To download full text click here

Meeting papers:

Gavrilova, N.S., Semyonova V.G., Evdokushkina G.N., Ivanova A.E. Problems with mortality data in Russia. Full Paper presented at the Annual Meeting of the Population Association of America (Philadelphia, March 31 - April 2, 2005, oral presentation), 22 pages. Abstract published in: Population Association of America 2005 Annual Meeting. Final Program and Abstracts. p. 294.
To download full text click here

Gavrilova N.S., Semyonova V.G., Evdokushkina G.N., Gavrilov L.A., Ivanova A.E. Recent mortality trends in Russia: Differences between younger and older generations. Paper presented at the Annual Meeting of the Population Association of America, Minneapolis, May 2003
To download full text click here

Gavrilova, N.S., Semyonova, V.G., Evdokushkina, G.N., Gavrilov, L.A. 2001. "Mortality crisis in Russia: New health threats". Paper presented at the 13th Meeting of the International Network on Health Expectancy (REVES-13), Vancouver, Canada
To download full text click here

Gavrilova, N.S., Evdokushkina, G.N., Semyonova, V.G., Gavrilov, L.A. 2001. "Economic crises, stress and mortality in Russia". Paper presented at the Annual Meeting of the Population Association of America (Washington, DC, March 23-25, 2001). Abstract published in: Population Association of America. 2001 Annual Meeting. Final Program and Abstracts. p.220-221
To download full text click here

Gavrilova, N.S., Semyonova, V.G., Evdokushkina, G.N., Gavrilov, L.A. 1999. "The response of violent mortality to economic crisis in Russia". Paper presented at the Annual Meeting of the Population Association of America (New York, March 25-27, 1999). Abstract published in: Population Association of America. 1999 Annual Meeting. Final Program and Abstracts. 1999, p.169.
To download full text click here

Ermakov, S.P., Antonyuk, V.V., Gavrilova, N.S., Evdokushkina, G.N. 1999. Factographic Automated Information Reference System (FAISS-"Potential"). In: K. Peter (ed.). Proceedings of the International Collaborative Effort on Automating Mortality Statistics, Volume 1. Hyattsville, MD: NCHS, 1999. DHHS Publication No.(PHS) 99-1252. 19-1-19-2.
To download full text click here

Gavrilova N.S., Evdokushkina G.N., Ermakov, S.P., Gavrilov L.A. An analysis of the health and mortality data for the provinces of Russia. In: International Population Conference. Beijing, 1997. Liege: IUSSP, 1997, vol.3, 1245-1257
To download full text click here

Gavrilova, N.S., Semyonova, V.G., Evdokushkina, G.N., Gavrilov, L.A. 2000. "Health responses to economic changes in Russia". Paper presented at the 12th Meeting of the International Network on Health Expectancy (REVES-12), Los Angeles, CA.
To download full text click here

Publications in Russian:

Ivanova A.E., Semyonova V.G., Gavrilova N.S., Evdokushkina G.N., Gavrilov L.A. Mortality trends: Role of particular age groups and causes of death in their shaping. Public Health and Disease Prevention [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2004, 6: 3-9.
To download full text click here

Abstract:
The study showed that the Russian mortality picture during the period of reforms had several features that significantly differed it from that in the Soviet period (1965-1984): first, a substantial "rejuvenation" of losses in life expectancies occurred at the expense of adolescent and young ages, whereas prior to the reforms mortality dynamics in these groups facilitated increase in life expectancies for women; second, deformation in the structure of causes of death occurred, which determine losses in life expectancies, evidencing marginalization of mortality, especially in young ages; third, during the period of reforms more negative tendencies in mortality in all ages over 15 years and from all causes are found in women. It is argued that the period of reforms became a stage of reverse development in epidemiological situation with increasing significance of public health problems relevant to the previous stages of the epidemiological transition.

Semyonova V.G., Dubrovina E.V., Gavrilova N.S., Evdokushkina G.N., Gavrilov L.A. On the problems of trauma mortality in Russia: Kirov region case. Public Health and Disease Prevention [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2004, 3: 3-10.
To download full text click here

Abstract:
The authors' hypothesis on underestimated traumatic mortality, especially at working ages, by masking predominantly mortality of the marginal populations under diagnoses of the IDC-10 class "Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified" is discussed. Individual mortality data for 2003 in the Kirov region had been analyzed. Arguments supporting underestimated mortality due to injuries and poisoning in various regions of Russia with high mortality rates due to inaccurately identified conditions at working ages are provided.

Semyonova V.G., Gavrilova N.S., Evdokushkina G.N., Gavrilov L.A. Data quality of medical statistics as a problem of modern Russian health care. Public Health and Disease Prevention [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2004, 2: 11-18.
To download full text click here

Abstract:
Quality of the Russian mortality statistics data is evaluated. As markers it is offered to use death rates in the class "Symptoms, features and inexactly identified conditions" according to the ICD-9, or "Symptoms, features and deviations from the norm" according to the ICD-10, as well as "Injuries, not specified "according to the ICD-9, or "Injuries with indefinite intents "according to the ICD-10. Mortality from inexactly identified conditions in 19892000 increased 5.9-fold in men and 8.3-fold in women, while mortality from injuries (not specified) increased 2.9 and 2.5 times accordingly, thus being significantly higher than the total mortality rate growth. It is shown that deterioration of the data quality has led to incorrect evaluation of the health priorities and as a result to inadequate management decisions.

Ivanova A.E., Semyonova V.G., Gavrilova N.S., Evdokushkina G.N., Dubrovina E.V., Gavrilov L.A. Russian mortality in 1965-2002 -- major problems and opportunities for decrease. Public Health and Disease Prevention [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2004, 1: 20-30.
To download full text click here

Abstract:
Age-specific and nosologic characteristics of the Russian mortality rates at various stages of their evolution during the period from middle 1960s until nowadays are analyzed. It is shown that the Russian mortality problems observed in the 21th century have developed primarily before the onset of the socio-economic reforms. The role of reforms expressed in acceleration of negative trends, deformation of the age-specific mortality curves, increase of losses because of exogenous causes which are preventable at the modern level of medical care. Using a series of measures based on death rate tables the gains in average lifespan from particular causes in various ages were determined

Ivanova A.E., Semyonova V.G., Gavrilova N.S., Evdokushkina G.N., Gavrilov L.A., Devichenskaya M.N. Age patterns of mortality in the urban and rural population of Russia in the 90s years of the 20th century. Disease Prevention and Health Promotion [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2003, 1: 17-26.
To download full text click here

Abstract:
Mortality rates characteristics of the Russian population in the main age groups -- infants under 1 year old (infant mortality), children of 1-14 years old (children's mortality), general population of 20-59 years old (mortality at working ages) and of the population older 60 years (mortality at the elderly ages) were analyzed. It was shown that, contrary to the common belief, the differences in mortality rates of urban and rural population are concentrated at children's ages, rather than working ages.

Semyonova V.G., Ivanova A.E., Gavrilova N.S., Evdokushkina G.N., Gavrilov L.A., Devichenskaya M.N. Medico-demographic conditions in urban and rural areas – similarity and differences. Disease Prevention and Health Promotion [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2002, 5: 8-14.
To download full text click here

Abstract:
Mortality rates in the urban and rural population of Russia in the 19990s were analyzed and compared. The study revealed: firstly, in the structure of mortality of rural population there was a noticeably higher proportion of causes of "unnatural" and violent death, as well as mainly exogenous causes, i.e. these were, to greater extent, both socially related causes and largely preventable ones at the current stage of public health development. Secondly, the mean age at death due to virtually all its causes was significantly younger in the rural population (both males and females) than in the urban one. At the same time the progression of unfavorable trends was much higher in the cities than in the villages.
It is hypothesized that a pattern of mortality formed in the rural population late in the 1980s had become a domain of attraction to which the mortality of urban population was evolving during the 1990s.

Semyonova V.G., Ivanova A.E., Gavrilova N.S., Evdokushkina G.N., Gavrilov L.A. Regional mortality variation as an indicator of health deterioration in the Russian population. Disease Prevention and Health Promotion [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2002, 4: 9-14.
To download full text click here

Abstract:
The distribution of mortality was studied in the main groups of the population by Russia's regions in the late 1990s. It was shown to be drastically changed during the economic reforms, these changes most significantly affected regions with high-mortality rates. In the course of the reforms, the Russian European North and its rural residents in particular, suffered most greatly.

Ivanova A.E., Semyonova V.G., Gavrilova N.S., Evdokushkina G.N., Gavrilov L.A., Demchenko T.A. Mortality in Russia in the 1990s and reserves of its reduction: Trends and forecasting. Disease Prevention and Health Promotion [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2002, 3: 9-19.
To download full text click here

Abstract:
The authors studied the trends in mean life expectancy in Russia since 1964. They estimated the levels of excess mortality in the 1990s and reserves for mortality decline for different age groups and causes of death in the future, up to the year 2015. The relatively low level of mortality observed in year 1989 was proposed as a potentially achievable goal for future possible recovery of public health in Russia. The mortality that is greater than in 1989 may be considered as excessive and regarded as loss reduction reserves. In the 1990s, total mortality rates at younger ages of 0-19 years were even lower than in 1989, while mortality had increased dramatically at older, working ages. In the 1990s, the overall excess mortality amounted to deaths of over 3 million individuals, mostly due to cardiovascular diseases (1,238 thousand excess deaths), injuries and intoxication (1,047 thousand excess deaths), and unspecified conditions (625 thousand excess deaths). Two thirds of excess losses of lives were shown to be accounted for males, mostly at their working ages, among them, 32.2% of male deaths and 23.6% of female deaths could have been prevented.

Semenova V.G., Gavrilova N.S., Varavikova Ye.A., Gavrilov L.A., Yevdokushkina G.N. Rise in violent death rates in Russia as a consequence of the economic crisis. Diseases Prevention and Health Promotion [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2000, 4: 3-10.
To download full text click here

Abstract:
A contribution of violent causes of death to the unprecedented peace-time mortality increases in Russia in the 1990s was studied. Changes in mortality due to violence (suicides, murders, traffic casualties, and incidental alcohol intoxications) in 1994 to 1997 were examined using official statistics. For this period, the average life span of Russian males and females reduced by 2.4 and 1.2 years, respectively. Throughout this period, mortality rates due to injuries and intoxications were extremely high: from 1993, this cause of death for males occupied the second place in the pattern of mortality. The same was true for females in some regions in certain years. The highest mortality due to injuries and other causes of death was observed in 1994, but despite its beginning decline, mortality from the above causes fell short of the initial level by 1997 by showing 1.4–1.8-fold increases in 1991–1997. The age-specific pattern of mortality from injuries and intoxications was explored in males and females of Russia. By analyzing the hypotheses explaining the increase in injury and intoxication mortality rates, the authors have concluded that its determinant is the alcoholization of Russia’s population that is greatly caused by the economic crisis.

Semenova V.G., Varavikova Ye.A., Gavrilova N.S., Evdokushkina G.N., Gavrilov L.A., Evolution of female mortality due to injuries and intoxications in some regions of Russia in the period of economic reforms. Diseases Prevention and Health Promotion [Obshch Zdor Profilac Zabol -- Общественное здоровье и профилактика заболеваний], 2000, 3: 29-31.
To download full text click here

Abstract:
The demographic consequences of economic reformation were studied in females, a one of the most vulnerable and unprotected groups of post-Soviet society. In 19891997, the average life-span expectancy of Russian females reduced by 1,5 years, which largely resulted from higher mortality due to violent causes of murders, suicides, accidental alcohol intoxication, and the so-called injuries (unspecified). The aim of the study was to examine processes occurring in the most unfavorable areas of the Russian Federation. It is concluded that the determining reason for higher mortality due to violent causes is the population’s alcoholization substantially caused by economic crises.

Wishlist

2009-12-20T20:06:00.001-08:00

Side effects of caloric restriction (CR): CR increases susceptibility to infections

2009-07-28T10:53:00.000-07:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

This is to invite you to discuss the side effects of caloric restriction (CR) that is often suggested for delaying aging and life extension. To initiate this discussion, a list of recent scientific publications is attached below (in reversed chronological order), which demonstrates that caloric restriction increases susceptibility to infections. You are most welcome to comment on these publications by clicking here, and to add more references to other studies on related topics. Thank you!

B. W. Ritz, I. Aktan, S. Nogusa, and E. M. Gardner (2008)
Energy Restriction Impairs Natural Killer Cell Function and Increases the Severity of Influenza Infection in Young Adult Male C57BL/6 Mice
J. Nutr., November 1, 2008; 138(11): 2269 - 2275.

Abstract:
Energy restriction (ER) without malnutrition extends lifespan in mice and postpones age-related changes in immunity. However, we have previously shown that aged (22 mo old) ER mice exhibit increased mortality, impaired viral clearance, and reduced natural killer (NK) cell cytotoxicity following influenza infection compared with aged mice that consumed food ad libitum (AL). To determine whether the detrimental effects of ER in response to influenza infection occur independently of advanced age, young adult (6 mo) male C57BL/6 mice consuming an AL or ER diet were infected with influenza A virus (H1N1, PR8). Young adult ER mice exhibited increased mortality (P < 0.05) and weight loss (P < 0.01) in response to infection. ER mice exhibited decreased total (P < 0.001) and NK1.1+ lymphocytes (P < 0.05) in lung and reduced influenza-induced NK cell cytotoxicity in both lung (P < 0.01) and spleen (P < 0.05). Importantly, the mRNA expression of interferon (IFN){alpha}/ß (P < 0.05) was also reduced in the lungs of ER mice in response to infection, and in vitro stimulation of NK cells from ER mice with type I IFN resulted in cytotoxicity comparable to that in NK cells from AL mice. In contrast, NK cell activation was enhanced in ER mice, determined as an increase in the percentage of NK cells expressing B220 (P < 0.001) and increased intracellular production of IFN{gamma} (P < 0.01). These data describe an age-independent and detrimental effect of ER on the innate immune response to influenza infection and suggest that a decrease in NK cell number and alterations in the NK cell-activating environment may contribute to decreased innate immunity in ER mice.

Deborah M. Kristan (2008)
Calorie restriction and susceptibility to intact pathogens
AGE, Volume 30, Numbers 2-3 / September, 2008, 147-156

Abstract:
Long-term calorie restriction (CR) causes numerous physiological changes that ultimately increase mean and maximum lifespan of most species examined to date. One physiological change that occurs with CR is enhanced immune function, as tested using antigens and mitogens to stimulate an immune response. Fewer studies have used intact pathogen exposure to test whether the enhanced capacity of the immune response during CR actually decreases susceptibility of hosts to their pathogens. So far, studies using intact bacteria, virus, and helminth worm exposure indicate that, despite similar or enhanced immune system function, CR hosts are more susceptible to infection by intact pathogens than their fully fed counterparts. Long-term CR studies that examine susceptibility to a variety of parasite taxa will help determine if direct CR or CR mimetics will be beneficial to people living in pathogen-rich environments.

Kristan DM (2007)
Chronic calorie restriction increases susceptibility of laboratory mice (Mus musculus) to a primary intestinal parasite infection.
Aging Cell, 2007, 6: 817–825.

Abstract:
Long-term calorie restriction (CR) has numerous benefits; however, effects of CR on susceptibility to intact pathogens are not well understood. Because CR enhances immune function of laboratory mice (Mus musculus), it was hypothesized that mice subjected to CR would be less susceptible to experimental infections of the intestinal parasite Heligmosomoides bakeri. Furthermore, because H. bakeri must combat a greater host immune response by CR mice compared to fully fed mice, it also was also hypothesized that (i) worms living in CR hosts would have lower reproduction than worms from ad libitum-fed mice, and (ii) CR mice would have a more female-biased sex ratio as male worms may be more vulnerable to host immune response than female worms. Mice were subjected to CR for 6.7 months and were then infected with H. bakeri for one additional month. As expected, CR mice had equal or enhanced immune response (eosinophils and immunoglobin G1 production) to H. bakeri infection compared to ad libitum-fed mice, and CR mice harbored a more female-biased sex ratio than ad libitum-fed mice. Contrary to predictions, CR mice had more worms than ad libitum-fed mice and the worms from CR mice produced more eggs than worms from ad libitum-fed mice. These data indicate that, despite the evidence that long-term CR enhances traditional measures of immune function, CR may actually increase susceptibility to intact parasite infection. Furthermore, changes in worm reproduction and differential survival of male vs. female worms may influence host-parasite transmission dynamics during long-term host CR.

Elizabeth M. Gardner (2005)
Caloric Restriction Decreases Survival of Aged Mice in Response to Primary Influenza Infection
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 60:688-694 (2005)

Abstract:
Caloric restriction (CR) extends life span of healthy rodents compared to those fed ad libitum. Previous studies have shown positive effects of CR on the immune response of aged mice after influenza immunization. To extend these studies, a mouse model of CR was used to determine if CR could modulate primary responses of aged mice to influenza. Although CR delayed the age-related decrease in mitogen-induced lymphoproliferation of aged mice, in stark contrast, CR decreased survival, increased virus titers, and reduced natural killer cell activity in lungs of aged mice after primary influenza infection. Thus, CR has differential effects on immunity of aged mice, as general indices of immune response are maintained, but primary responses to influenza infection are impaired. This suggests that, although CR may positively affect many long-term parameters of aging, increased susceptibility after primary exposure of aged mice to virus, such as influenza, may not be correctable by CR.

Karen Hopkin (2003)
Dietary Drawbacks
Sci. Aging Knowl. Environ., 26 February 2003, Vol. 2003, Issue 8, p. ns4

Abstract:
A growing number of researchers are finding that calorie restriction is not all it's cracked up to be. The regimen--long hailed as the only way to retard aging in a wide variety of animals--produces some distasteful side effects and doesn't always work.
The benefits of dietary restriction are well documented: Creatures that consume one-third fewer calories are leaner, livelier, and longer lived than their fully fed kin. But such drastic dieting also has a dark side. Restricted animals get chilled and pick up infections unusually easily, and they're less fertile than their more portly compatriots are. Furthermore, cutting calories doesn't enhance longevity in all animals, according to several studies. These observations have many researchers wondering what dietary restriction--or a drug that mimics its effects--might do for people who are hoping to live longer and healthier lives.
Lay down your fork and extend your life-span! It's not a scam but a sentiment that finds equal welcome in blockbuster diet books and gerontological journals. Backed by more than 6 decades of solid research, scientists tout calorie restriction (CR) as the only intervention that retards aging and lengthens life-span in a variety of creatures, from yeast and worms to laboratory mice and rats (see Masoro Review and "Aging Research Grows Up"). Although studies on primates are still in their infancy, some people interested in prolonging their lives are already putting the idea into practice.
But is this antiaging wonder diet really the greatest thing since saying no to sliced bread? Despite their enhanced longevity, animals consuming 20% to 40% fewer calories than their well-fed brethren might not be the picture of perfect health, according to a growing number of studies. The results suggest that dietary restriction has its drawbacks, and that researchers will need to separate its benefits from its less savory side effects before applying it to humans. At the same time, studies in Mediterranean fruit flies and certain strains of mice indicate that cutting calories does not guarantee long life in all animals, leading some scientists to question anew whether CR--or a pill that might mimic its effects on aging--would ever work in people.

Sun D, Muthukumar AR, Lawrence RA, Fernandes G (2001)
Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL/6 mice.
Clin Diagn Lab Immunol , 2001, 8: 1003–1011.

Abstract:
Calorie restriction (CR) is known to prolong the life span and maintain an active immune function in aged mice, but it is still not known if rodents under CR can respond optimally to bacterial infection. We report here on the influence of CR on the response of peritoneal macrophages to lipopolysaccharide, splenic NF-kappa B and NF-interleukin-6 (IL-6) activities, and mortality in polymicrobial sepsis induced by cecal ligation and puncture (CLP). Macrophages from 6-month-old C57BL/6 mice on a calorie-restricted diet were less responsive to lipopolysaccharide, as evidenced by lower levels of IL-12 and IL-6 protein and mRNA expression. Furthermore, in vitro lipopolysaccharide-stimulated macrophages from mice under CR also expressed decreased lipopolysaccharide receptor CD14 levels as well as Toll-like receptor 2 (TLR2) and TLR4 mRNA levels. In addition, the phagocytic capacity and class II (I-Ab) expression of macrophages were also found to be significantly lower in mice under CR. Mice under CR died earlier (P < 0.005) after sepsis induced by CLP, which appeared to be a result of increased levels in serum of the proinflammatory cytokines tumor necrosis factor alpha and IL-6 and splenic NF-kappa B and NF-IL-6 activation 4 h after CLP. However, mice under CR survived significantly (P < 0.005) longer than mice fed ad libitum when injected with paraquat, a free radical-inducing agent. These data suggest that young mice under CR may be protected against oxidative stress but may have delayed maturation of macrophage function and increased susceptibility to bacterial infection.

See also:
-- New Books on Caloric Restriction
-- Life Extension, Caloric Restriction and Scientific Philanthropy

Key words:
Caloric restriction, Calorie restriction, CR, Dietary restriction, DR, Energy Restriction, ER, susceptibility to infections, Influenza, pathogens, delaying aging,life extension

To read comments on this topic and to participate in further discussions by posting your own thoughts and suggestions, you are welcome to click here.

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Side effects of caloric restriction (CR): CR increases susceptibility to infections
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Stress Reduction and Mood Enhancement with Guerlain

2009-03-30T16:25:00.001-07:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

I am looking for ways to reduce stress level and enhance mood for one of my female scientific colleagues. I know that she likes Guerlain. So would this be a right choice?:

Insolence By Guerlain For Women Eau De Toilette Spray, 3.4-Ounces

Please advise.

Thank you!

Oral Health: Peri-Gum Mouthwash Concentrate

2009-03-19T17:32:00.000-07:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

I wonder whether anybody here tried this product, to comment on its efficacy:

Peri-Gum Mouthwash Concentrate 1 Oz

Here is what they claim (no endorsement implied):

Product Description:
PERI-GUM(r) Mouthwash is a concentrated formulation of herbal extracts and essential oils, each one known by herbal health authorities for their ability to improve oral health. Now combined for the first time to release their synergistic powers as Nature's Gum Solution. PERI-GUM(r) was clinically tested in a 4 week pilot study at a major Northeastern University and was found to be safe to oral tissues. The reduction in gingival health scores was 20% and the reduction in plaque scores was 16%.

Key words:
Oral Health, Peri-Gum Mouthwash Concentrate, herbal extracts, essential oils, northeastern university, gingival health, plaque score

Skin Care: Derma Roller

2009-01-30T12:49:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

I wonder whether anybody here tried this device, to comment on its efficacy:

Derma Roller, New Dermaroller 1.0 mm , Wrinkles, Scars, Acne

Here is what they claim (no endorsement implied):

Product Description:

This model is designed to induce the body's own production of collagen. Its needles have a length of 1.0 mm. The needles induce body own collagen (CIT) in deeper skin layers to strengthen the connective tissue and to minimize the typical "orange-skin-appearance". It is equipped with 192 stainless steel needles in 8 rows. Needle diameter: 0.25 mm. The model has a width of 20 mm.

How to use the derma roller:

1. Cleanse Face / Areas to be treated. Apply it in the horizontal, vertical, diagonal direction in entire face area.

2. Apply Serums / Solutions / Pure Vitamins Aqua & Roll the Derma Roller over the skin back and forth several times in different directions. Do not press too hard as it is not necessary for success. As a general guide, roll the Derma Roller over the area to be treated 10 times or 2-3 minutes.

3. After treatment, please protect your skin with Sun Block & try to refrain from cosmetics & make-up for 2~3 days as the skin is regenerating new recovery from the dermis & stimulating collagen production naturally. Each roller lasts 2-4 months.

Product Features:

- Facelift scars
- Hair transplantation scars
- Surgical abdominal scars
- Breast plastic operation scars
- Burn contractures

Key words:

Derma Roller, Dermaroller, Collagen, Skin care

Skin Care

2009-01-28T12:01:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

I wonder whether anybody here tried this device, to comment on its efficacy:

DR.ROLLER BRAND NAME, DERMA ROLLER 0.5mm,FDA APPROVED,WRINKLES,SCARS,HAIR LOSS,STRETCH MARKS,BALDNESS,ACNE.

Here is what they claim (no endorsement implied):

Product Features

*After treatment for Wrinkles,Stretch Mark,Acne,Hair Loss, skin is thickened, tightened and elasticity restored, leaving a healthy youthful appearance.

*Dr. Roller 0,5mm a non-surgical tool and is safe for normal, sensitive & dark skin. Anti-aging, cellulite and stretch mark removal is now made easy in the privacy of your own home.

*Dr. Roller a needling a device called a DERMA-ROLLER is a fairly new procedure in cosmetic medicine, for the stimulation of new collagen fibres and other skin cells. In contrast to other techniques such as acids or laser it does not damage or peel the epidermis

*Dr. Roller 0.5mm has 192 STERILIZED needles to pin point skin punctures into the dermis of the skin. This damage induces the release of growth factors that stimulate the production of collagen and elastin. It is common knowledge that the body reacts to any injury and triggers the wound healing process. This process of remodelling can go on for up to 12 months after each treatment. Dramatic results can be seen within one week.

*Remove stretch marks & cellulite any where on the body. Improve blood supply to the area,Removes acne or surgical scars,heavy pitted skin - sun damage -hyper pigmentation - upper lip lines, lines & wrinkles,Improve thinning hair, greying hair and hair loss/alopecia

Product Description

* Dr. Roller consists of 192 STERILIZED High strength stainless steel Needles.Most other companys do not STERILIZE There roller Needles,they just Specially Treat there needles and that why they can not say STERILIZED NEEDLES in there Ads.If there needles are Sterilized it has to say it on the outside of the box,Make sure you ask before you buy.

* DR.ROLLER Removes old collagen fibres, clears blocked pores, stimulates blood flow, and rapidly stimulates new collagen growth.

*DR. ROLLER Dramatically increases the effectiveness of your hair and skin care products through increased penetration

*DR. ROLLER Stimulates blood flow through directly massaging the scalp, face and body. *DR. ROLLER Gentle exfoliation of dead skin cells accumulating in the hair follicles, face and body.

*The DR. ROLLER process is not painful (A tickling sensation.)

LifeCell Anti-Wrinkle Cream Anti-Aging Skin Care ~ Botox Alternative

2008-03-16T08:07:00.000-07:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

I wonder whether anybody here tried this cream, to comment on its efficacy:

LifeCell Anti-Wrinkle Cream Anti-Aging Skin Care
~ Botox Alternative ~ 2.54 ounces

Here is what they claim (no endorsement implied):

Product Features

- LifeCell intensely moisturizes and nourishes your skin... like it has never been moisturized before ever!
- LifeCell reduces the appearance of discolorations and imperfections.
- LifeCell reduces the appearance of under-eye puffiness and dark circles.
Lips appear fuller; fine lines around the mouth appear smoothened and lip "bleed" is prevented.
- LifeCell helps stimulate production of collagen, helping lines, wrinkles and unsightly "crow's feet" to look more smoothened out, lifted away.

Ingredients:

Dithiolane-3-Pentanoic Acid:
According to the Mayo Clinic Dithiolane-3-Pentanoic Acid is an antioxidant that penetrates skin cell membranes, where it neutralizes free radicals and increases the effectiveness of other antioxidants such as vitamins C and E.

Ascorbyl Palmitate:
Fat soluble form of Vitamin C. According to the Mayo Clinic, Topical vitamin C may reduce wrinkles, thicken skin and protect against sun damage. Vitamin C is an antioxidant nutrient that helps recycle vitamin E.

Deanol:
Considered a great ingredient to treat sagging skin. Speaking at the American Academy of Dermatology meet, Dr. Patricia Farris excitedly said. "This is the first time that we have seen evidence that any topical treatment could be helpful in treating the anatomic [muscular] changes that occur as a result of aging.

Idebenone:
A group of researchers developed the first ever protocol to compare the efficacy of antioxidants. They tested and compared 6 of the most potent antioxidants (including Ibedenone), known to science, on their effects on preventing free-radical skin-damage.

Acetyl Hexapeptide-3:
AH3 blocks the nerve signals (neurotransmitters) that control the contraction of facial muscles. This produces a significant reduction in both the depth and size of dynamic fine lines and wrinkles.

Regu:
LifeCell also has a proprietary Swiss formulation consisting of specially purified soy and rice peptides and yeast protein produced biochemically.

Directions:
A. Using the ring finger or pinkey - dot LifeCell along the edge of the orbital bone - the bone directly under the eye. Two dots of LifeCell should be sufficient to cover the area. Gently pat (do not rub!) the cream into the skin - staying around the edge of the bone. Do not get closer! LifeCell, once absorbed into the skin, will spread.

Product Description:
Columbia University Trained Plastic Surgeon Discovers Revolutionary New Breakthrough In Skin care Science That Makes Lines And Wrinkles Virtually Vanish Before Your Very Eyes!

24-Hour Moisturizer:
LifeCell intensely moisturizes and nourishes your skin... like it has never been moisturized before ever! (Many pharmacists believe LifeCell is the best moisturizer in the world because it can penetrate through 20 skin cell layers.) It's a welcome surge of relief you feel instantly.

Natural Collagen Stimulator:
LifeCell helps stimulate production of collagen, helping lines, wrinkles and unsightly "crow's feet" to look more smoothened out, lifted away. Wrinkles appear pushed up and out as though plumped from within.

Microlifter & Firmer:
LifeCell's 25,000 microlifters immediately form a network to help make your skin look tighter and firmer. (On average, women over 40 have over 25,000 micro-points on their face which LifeCell's microlifters target.)

Age Spots:
LifeCell reduces the appearance of discolorations and imperfections.

Beautiful Eyes:
LifeCell increases balance of moisture in the gentle skin around eyes. Eyelids appear lifted, eyes look recountoured and wide-open.

Serious Dark Circles & Under-Eye Puffiness?
LifeCell reduces the appearance of under-eye puffiness and dark circles. And this happens at the same time... LifeCell reduces the appearance of eye puffiness and dark circles.

Lip Plumper:
Lips appear fuller; fine lines around the mouth appear smoothened and lip "bleed" is prevented. Your "provocative pout" remains soft, moist, seductive... all day, all night! With continued use your lips' natural color looks restored.

Living Long and Loving It: Achieving a Healthy and Active Lifestyle (New Book)

2008-02-24T13:06:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here (click on the book title below for more detail):

Living Long and Loving It: Achieving a Healthy and Active Lifestyle
by Irvin M. Korr and Rene J. McGovern (Paperback - Jan 31, 2008)

Book Description provided by the Publisher (Prometheus Books):

Stereotypes about the elderly are so prevalent that elders themselves often buy into them. People young and old assume that retirement is a time of inactivity, less social involvement, and inevitable physical decline. For over nine decades Dr. Irwin M. Korr was a living refutation of that dreary stereotype. Through a holistic approach to health, based on the principles of osteopathic medicine, he proved that healthy, vigorous, fulfilling old age and long life are the natural culmination of healthy living. In his eighties, Dr. Korr was regularly playing tennis and cross-county skiing, while continuing his career as a medical educator, researcher, author, and lecturer.

In this inspiring guide to achieving a healthy lifestyle at any time of life, Dr. Korr explains with enthusiasm and great clarity how any reader can apply scientifically based osteopathic principles to improve quality of life and promote successful aging. Among the principles he stresses is that the human body incorporates its own healing and defensive systems, as well as a health maintenance system. Together they form an indwelling healthcare system that is the ultimate source of health and for which each individual must take primary responsibility. By learning to develop healthy habits, we take care of the "physician within" to ensure that our inner physician can then take care of us.

Dr. Korr also emphasizes the importance of regular exercise and the beneficial effects that freedom of motion and physical activity bring, not only on our musculoskeletal system but also for our various internal organs, as well as our state of mind. He recommends stretching exercises such as Yoga and whatever workout routine an individual finds enjoyable, from walking to jogging, swimming, and bicycling. Finally, he makes the point that healthy aging is a choice that anyone can make at any time of life by making beneficial lifestyle changes.

About the Author:

Irvin M. Korr, PhD (1909-2004), was widely known and regarded for his writing in the fields of medical education, medical philosophy, and heath promotion. He spent most of his career at Kirksville College of Osteopathic Medicine, but also worked at New York University School of Medicine, Michigan State College of Osteopathic Medicine, and the University of Texas School of Osteopathic Medicine. He wrote numerous articles and several books, mostly on the human nervous system and the physiological basis for osteopathic medicine.

Rene J. McGovern, PhD (Kirksville, MO), is a geriatric and health psychologist and professor of neurobehavioral sciences and community and family medicine at A.T. Still University in Kirksville, MO. She is also on the faculty of the department of psychiatry at Case Western Reserve University School of Medicine in Cleveland, OH. She has lectured nationally and internationally on geriatrics and behavioral health and headed the federally funded ElderLynk project to integrate mental health in primary care for the elderly. She is the coauthor, with J.J. McGovern, of Your Healer Within: A Unified Field Theory of Healthcare, as well as many articles in peer-reviewed academic journals.

Key words:
New books, Living Long, Active Lifestyle, Irvin Korr, Prometheus Books, elderly, retirement, holistic approach, osteopathic medicine, successful aging, exercise, Yoga, healthy aging, medical education, medical philosophy, heath promotion, geriatrics, ElderLynk project

Do you have any comments on this new book?
Post them below!

Essentials of Geriatric Physical Therapy (New Book)

2008-02-22T07:32:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here (click on the book title below for more detail):

Essentials of Geriatric Physical Therapy
by Jennifer M. Bottomley, Ph.D. (Hardcover - Jan 31, 2008)

Publisher: Prentice Hall

Key words:
New books, Geriatric Physical Therapy, Physical Therapy, Jennifer Bottomley, geriatrics, geriatric

Do you have any comments on this new book?
Post them below!

"Beat Memory Loss: The Complete Guide to Making the Most of Your Memory" (New Book)

2008-02-21T08:47:00.001-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here:

Beat Memory Loss:
The Complete Guide to Making the Most of Your Memory
(Use Your Brain to Beat... S.)
by Rita Carter (Paperback - Jan 30, 2008)

Publisher: Cassell

Key words:
New books, Beat Memory Loss, Rita Carter, Cassell

Do you have any comments on this new book?
Post them below!

"Smile for Life: Rejuvenation Dentistry and the Art of Wellness" (New Book)

2008-02-20T15:33:00.001-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here:

Smile for Life:
Rejuvenation Dentistry and the Art of Wellness
by Gerald P. Curatola (Paperback - Jan 30, 2008)

Publisher: Mdpublish.com

Key words:
New books, Smile for Life, Rejuvenation Dentistry, Art of Wellness, Gerald Curatola, Mdpublish.com

Do you have any comments on this new book?
Post them below!

New Book -- "Ultra-Longevity: The Seven-step Program for a Younger, Healthier You"

2008-02-19T07:09:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here:

Ultra-Longevity:
The Seven-step Program for a Younger, Healthier You
(Thorndike Large Print Health, Home and Learning)
by Mark Liponis (Hardcover - Jan 22, 2008) - Large Print

Book Description provided by the Publisher (Thorndike Press):

Medical director of the world-famous Canyon Ranch Health Resorts, Dr. Mark Liponis presents his extraordinary new idea: that aging and aging-related diseases---including heart disease, cancer, and diabetes---are autoimmune problems, and that a well-managed immune system is the key to healthy aging. Cutting-edge research makes UltraLongevity the first and only book to explore aging within the context of the immune system, and it will change the way we look at health forever. Starting with a quiz---"How Fast Are You Aging?"---Liponis explains the new science, lays out an accessible and proven 7-step program with an 8-day meal plan, and motivates readers to put the program into practice so that they can keep their minds sharp, become more physically fit, be more resistant to infections and disease, and feel and stay younger than they ever imagined. Through the UltraLongevity program, Liponis promises more than a long life; he promises a long, healthy life.

Advance praise for UltraLongevity:

-- "What an awesome and practical anti-aging program! Dr. Liponis's approach to longevity is based on proven technological breakthroughs supported by hundreds of studies. This is the best original thinking I have seen in decades!" - Stephen T. Sinatra, MD, FACC, CNS, coauthor of Reverse Heart Disease Now

-- "UltraLongevity is a treasure - it's loaded with exactly the kind of information everyone needs to live well and vibrantly - for as long as possible." - Christiane Northrup, MD, author of Women's Bodies, Women's Wisdom

-- ". . . an insightful, simplified, and integrated approach to achieving optimal health, wellness, and longevity." - Richard Carmona, MD, MPH, FACS, 17th Surgeon General of the United States.

Key words:
New books, Ultra-Longevity, Mark Liponis, Thorndike Press, aging, aging-related diseases, heart disease, cancer, diabetes, autoimmune problems, immune system, anti-aging, longevity

Do you have any comments on this new book?
Post them below!

New Book -- "Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late"

2008-02-18T07:45:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here:

Reverse Heart Disease Now:
Stop Deadly Cardiovascular Plaque Before It's Too Late
by Stephen Sinatra, James C. Roberts, M.D., and Martin Zucker (Paperback - Jan 18, 2008)

Book Description provided by the Publisher (Wiley):

While most books focus solely on the role of cholesterol in heart disease, Reverse Heart Disease Now draws on new research that points to the surprising other causes. Two leading cardiologists draw on their collective fifty years of clinical cardiology research to show you how to combine the benefits of modern medicine, over-the-counter vitamins and supplements, and simple lifestyle changes to have a healthy heart.

From the Back Cover:

"Drs. Sinatra and Roberts have taken preventive cardiology to an entirely new level. . . . I highly recommend this important and groundbreaking new book."
Nicholas Perricone, M.D., bestselling author of The Perricone Prescription and Dr. Perricone's 7 Secrets to Beauty, Health, and Longevity

"A must-read for anyone interested in stopping heart disease in its tracks. If you want to live a long and healthy life, this is the book for you."
Dharma Singh Khalsa, M.D., bestselling author of Brain Longevity

Leading cardiologists Dr. Stephen Sinatra and Dr. James Roberts draw on their collective fifty years of clinical cardiology research to show you how to combine the benefits of modern medicine, over-the-counter vitamins and supplements, and simple lifestyle changes to have a healthy heartwhether you have acute or chronic disease or just want to prevent cardiovascular disease from developing. You'll discover how:

-- You can combat heart disease before the first heart attack

-- Medications, scientifically proven supplements, and lifestyle changes can extinguish the flames of disease and purge and stabilize arterieseven for the most compromised cases

-- Fish oil, nattokinase, L-arginine, and other supplements can help prevent arterial clogging

-- CoQ10, along with L-carnitine and D-ribose, can powerfully recharge weak and ailing hearts

Key words:
New books, Heart Disease, Cardiovascular Plaque, Stephen Sinatra, James Roberts, Martin Zucker, Wiley, cholesterol, vitamins, supplements, lifestyle, Fish oil, nattokinase, L-arginine, CoQ10, L-carnitine, D-ribose, arterial clogging

Do you have any comments on this new book?
Post them below!

New Book -- "From Belly Fat to Belly Flat: How Your Hormones Are Adding Inches to Your Waist and Subtracting Years from Your Life..."

2008-02-17T11:09:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here:

From Belly Fat to Belly Flat:
How Your Hormones Are Adding Inches to Your Waist and Subtracting Years from Your Life -- the Medically Proven Way to Reset Your Metabolism and Reshape Your Body
by M.D., C.W. Randolph and Genie James (Paperback - Jan 15, 2008)

Book Description provided by the Publisher (HCI):

Discover the hidden culprit behind the 'middle-age spread' -- and the simple plan that's helped hundreds of women over 30 break the fat cycle! I t's an all-too-common problem once you hit thirty: Despite your best efforts, you just can't seem to lose the extra weight around your middle, and you look in the mirror wondering what month and year you lost your waistline. Medical research proves you're not alone -- that the average American gains one to two pounds a year after age thirty -- usually around the stomach. Not only does this excess belly fat make you look and feel bad, it's the most damaging kind of fat; a precursor to heart attacks and certain types of cancer. To the contrary of other diet books, C.W. Randolph, M.D., a champion for women's health, explains that the real reason behind this problem has less to do with calories, carbs, or crunches and everything to do with a little-known but very real medical problem called 'estrogen dominance.' By treating thousands of women safely and effectively for over two decades, Dr. Randolph has discovered why we are in the midst of an estrogen epidemic and how you can save your waistline... and your health... using his 3-step plan comprised of an anti-estrogenic diet, natural progesterone supplementation, and exercise. You'll learn:
-How to self-diagnose estrogen dominance
-The top ten belly-blasting foods that jump-start weight loss and maintain hormone balance
-How your sleep patterns, exercise habits, and stress levels impact your hormone levels
-Which vitamins and supplements support, not sabotage, your overall hormone balance.

The result? Well within four weeks you'll lose pounds and inches' and reveal the flat belly -- and the health and vitality that go along with it.

Key words:
New books, belly fat, Hormones, C.W. Randolph, Genie James, HCI, women's health, estrogen dominance, estrogen, anti-estrogenic diet, progesterone, exercise, sleep, stress, vitamins, supplements, weight loss

Do you have any comments on this new book?
Post them below!

New Book -- The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow

2008-02-16T12:01:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here:

The Natural Hormone Makeover:
10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow
by Phuli Cohan (Hardcover - Jan 14, 2008)

Book Description provided by the Publisher (Wiley):

During both perimenopause and menopause it is estimated that 800f all women suffer significant life altering symptoms such as fatigue, depression, low sex drive, hot flashes, vaginal dryness, recurrent urinary tract or vaginal infections, insomnia, and more. Many large-scale studies have been done looking at the safety of hormones. Unfortunately the largest studies in this country have looked at the safety and benefits of synthetic hormones given orally, primarily using horse estrogen (Premarin) and synthetic progesterone (Provera, or Medroxy progesterone). Medical evidence continues to mount against artificially replacing hormones (HRT), which paves the way for this all-natural approach to hormone rejuvenation.

From the Inside Flap:

"After having experienced various difficult perimenopausal and menopausal symptoms for years, I was helped greatly by Dr. Phuli Cohan's unique approach to treatment, which integrates elements of her training in Western, Chinese, and Ayurvedic medicines."
Nina Simonds, author of A Spoonful of Ginger and Spices of Life

Perimenopause, the five to fifteen years before menopause, is fraught with symptoms that are often ignored, or worse, tolerated. You can't avoid perimenopause or menopause, but you can avoid the suffering, loss of energy, and emotional ups and downs that accompany them. You can also retain your skin and muscle tone, feel as vigorous and healthy as ever, and enjoy an active sex life. And you don't have to risk your long-term health to do it.

In The Natural Hormone Makeover, a female doctor who has spent more than two decades studying the relationship between hormones and menopause presents a safe and effective program for using natural and bioidentical hormones to combat hot flashes, insomnia, mood swings, fatigue, breast pain, hair loss, low sex drive, and many other symptoms linked to menopause-related hormone imbalances.

This easy-to-follow ten-step treatment program educates and empowers you to make the best choices to improve your symptoms and feel healthier, happier, and sexier. Combining traditions of Chinese medicine with the latest Western developments and discoveries, this regimen helps you create a personalized course of treatment using supplements, herbs, natural and bio-identical hormones, and diet to enhance both safety and hormone effectiveness.

You'll learn everything you need to know about:

-- The seven different forms of estrogen and how their "personalities" affect you

-- Bioidentical hormones and why they are safer and more effective than hormone replacement therapy

-- The importance of the adrenal gland in improving symptoms and slowing the aging process

-- Cutting-edge discoveries concerning hormone metabolism, dietary supplements, and safety

-- Altering the effects of lifestyle, environment, and genetics on hormone balance

-- Chinese herbal treatments and why they help you to metabolize your body's own hormones more completely

-- Assembling a team of health professionals to ensure the safety and effectiveness of your hormone makeover

If you've been confused about your health and whether you need or can use hormones safely, you're not alone. Judging by the rash of false claims, misguided warnings, and faulty explanations in recent years, so are many of the so-called experts. The Natural Hormone Makeover gives you clear, authoritative, scientifically proven in-formation you can trust. Read it and start to rediscover your inner glow today.

Key words:
New books, Natural Hormone Makeover, Phuli Cohan, Wiley, perimenopause, menopause, fatigue, depression, low sex drive, hot flashes, vaginal dryness, recurrent urinary tract or vaginal infections, insomnia, Premarin, Provera, Medroxy progesterone, HRT, bioidentical hormones, mood swings, breast pain, hair loss

Do you have any comments on this new book?
Post them below!

The Vitamin D Cure (New Book)

2008-02-15T14:00:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here:

The Vitamin D Cure
by James Dowd and Diane Stafford
(Hardcover - Jan 14, 2008)

Book Description provided by the Publisher (Wiley):

Advance praise for The Vitamin D Cure

"The Vitamin D Cure is a revolutionary way to think about health and disease. My daughter suffered from a severe vitamin D deficiency and correcting it made a positive difference in her life. This book is practical and easy to read, and it offers hope for millions of people who suffer from pain, low energy, obesity, or depression."
Daniel Amen, M.D., Director, Amen Clinics, Inc., and author of Making a Good Brain Great and Change Your Brain, Change Your Life

"For decades nutritional scientists assumed that recommended intakes of vitamin D prevented bone disease but offered few other health benefits. In this skillfully written book,Dr. Dowd expertly explains how vitamin D is actually a hormone whose insufficiency represents one of the most widespread health problems in the United States. By following the individualized program of supplementation and sun exposure outlined in this book, the risk for numerous chronic diseases can be reduced."
Loren Cordain, Ph.D., author of The Paleo Diet

"This is a timely and unique book that highlights the importance of vitamin D in the prevention and control of many common conditions, including diabetes, high blood pressure, and cardiovascular disease. Recent clinical studies have documented the fact that most people are vitamin D deficient and that taking vitamin D supplements can reduce the risk of dying from all diseases. Dr. Dowd's five-step plan provides insight into the wonders of the forgotten vitamin and offers a practical and user-friendly game plan to place us on the road to heart health and a longer life."
Jennifer H. Mieres, M.D., Associate Professor of Medicine and Director of Nuclear Cardiology at the New York University School of Medicine, coauthor of the Heart Smart Guide for Black Women and Latinas

"Vitamin D is truly a miracle vitamin – it is fundamentally important to health and fighting many different diseases. And yet most people don't come close to obtaining optimal amounts. In this book, Dr. James Dowd explains everything you need to know about vitamin D and how it can improve your health."
Jack Challem, author of Stop Prediabetes Now, The Inflammation Syndrome, and The Food-Mood Solution

"It is rare these days to have clear and understandable explanations of medical science. Fortunately, Dr. Dowd has the knowledge and has taken the time to provide some excellent insights into the health advantages available to everyone through natural environmental resources like vitamin D. The writers of this book are to be highly commended and thanked."
Benjamin S. Carson, Sr., M.D., Director of Pediatric Neurosurgery and Professor of Neurological Surgery, Oncology, Plastic Surgery, and Pediatrics, the Johns Hopkins Medical Institutions

From the Inside Flap:

It may sound too good to be true, but it's actually solid medicine based on real science: groundbreaking new research has traced the source of a wide array of disorders that afflict up to 200 million Americans to a single common factor - vitamin D deficiency. Increasing the amount of vitamin D in your body can cure or help treat a remarkable number of ailmentsfrom obesity to arthritis, from high blood pressure to back pain, from diabetes to muscle cramps. If you suffer from these or many other chronic health problems, you may wonder whether you are getting enough vitamin D and what to do about it.

In The Vitamin D Cure, leading rheumatologist and researcher Dr. James Dowd reveals the causes of vitamin D deficiency and explains why North Americans are particularly vulnerable to it. He then offers a simple, easy-to-follow five-step program that can eliminate or alleviate a host of seemingly incurable conditions, such as arthritis, in as little as six weeks. Better yet, by staying on the program, you can enjoy robust health and improved fitness for the rest of your life.

Citing numerous scientific studies, a wealth of clinical data, and case stories from his practice, Dr. Dowd shows how lifestyle and diet have combined to reduce the vitamin D intake of most of us who live north of the equator. Eating the wrong foods, not getting enough exercise, and spending too much time indoors have produced a major health crisis.

The good news is that you can greatly improve your health with the five easy steps in this life-changing guide. You'll learn how to:

-- Find out how much vitamin D you need

-- Sun and supplement your way to great D levels

-- Calculate your acid excess and tweak your diet

-- Cover your bases with total supplementation

Add a little exercise to the mix

More than you ever realized, the future of your health is in your hands. You can harness the power of the "sunshine vitamin" to transform your life, end your pain, and return to active, vigorous well-being now and for decades to come. Read The Vitamin D Cure and start letting the sun shine on your health and your life.

Key words:
New books, Vitamin D, James Dowd, Diane Stafford, Wiley, obesity, arthritis, blood pressure, back pain, diabetes, muscle cramps

Do you have any comments on this new book?
Post them below!

The Myth of Alzheimer's: The Story of a Disease, a Doctor, and a New Direction for Aging in the 21st Century (New Audio Cassette)

2008-02-14T13:53:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new audio cassette for discussion here:

The Myth of Alzheimer's:
The Story of a Disease, a Doctor, and a New Direction for Aging in the 21st Century
by Whitehouse M.d., Peter J. ph.d, Danny George, and Julie M. Fenster
(Audio Cassette - Jan 8, 2008)

Product Description provided by the Publisher (Blackstone Audio, Inc.):

This is a call to arms to re-evaluate the way we think about and deal with Alzheimer's disease. The author puts forth that the current view of Alzheimer's as a virtual death sentence obscures the potential for vitality and wisdom that still exists in the graying years. He posits that there is a wide range of cognitive impairment and that the trajectory does not necessarily end in the deepest throes of senility, impaired body function, and dependence on twenty-four-hour care. He contends that the label of Alzheimer's generates fear, paranoia, and anxiety, and by taking a closer look at what Alzheimer's is and isn't, he can offer hope to individuals, as well as their families, who suffer from a decline in their cognitive abilities. He presents a new approach to the treatment of brain aging, using examples from his own practice as well as from around the world, and provides practical information so that readers can get the best level of care for themselves or their loved ones.

About the Authors:

PETER J. WHITEHOUSE, M.D., Ph.D., is the director of integrative studies in the Department of Neurology at Case Western Reserve University and is the founding director of the University Memory and Aging Center at Case. He is a clinician at Elder Health Center at University Hospital of Cleveland.

DANNY GEORGE works at the Memory and Aging Center in Cleveland, Ohio, and is currently pursuing a master of science degree in medical anthropology at Oxford University in England.

Key words:
New Audio Cassette, Myth of Alzheimer's, Alzheimer's, Peter Whitehouse, Danny George, Julie Fenster, Blackstone Audio, cognitive impairment, senility, brain aging, Elder Health, aging, Neurology, memory

Do you have any comments on this new audio cassette?
Post them below!

New Book -- The 30-Minute Celebrity Makeover Miracle: Achieve the Body You've Always Wanted

2008-02-10T12:41:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion here:

The 30-Minute Celebrity Makeover Miracle:
Achieve the Body You've Always Wanted
by Steve Zim and Steve Steinberg (Hardcover - Jan 2, 2008)

Book Description provided by the Publisher (Wiley):

Praise for Steve Zim and The 30-Minute Celebrity Makeover Miracle

"Steve Zim's plan helped me drop my body fat more quickly than with any other program I've ever tried. I couldn't be more pleased."
Jessica Biel

"Within only eight weeks of working with Steve Zim, Steven Strait made a huge change to his body for his role in 10,000 BC. He looked amazing, and that was important since his body was such an integral part of his role."
Roland Emmerich, director of 10,000 B.C. and Independence Day

"Steve Zim got me in shape quickly and made me ready for competition. I feel great and people tell me I look great."
Laila Ali, contestant, Dancing with the Stars

"Steve Zim is one of the best trainers I've worked with. I never challenged myself to run, but he helped me reach a 5K that was featured in Self Magazine. I get bored working out very easily, but Steve is so creative with his exercises that I actually look forward to hitting the gym. You actually are having fun while getting your tush in shape!"
Shaun Robinson, host, Access Hollywood

"Steve Zim not only got me in the best shape of my life, but his enthusiasm and strategy keep me going. Steve's program makes me feel completely empowered and I have never felt better mentally or physically."
Stryker, dj, The Ellen DeGeneres Show

"Think you're out of luck? Think again. Extra's Dayna Devon lost 20 lbs just in time for her wedding using the world's speediest diet and exercise tricks by Steve Zim."
Woman's World magazine

From the Inside Flap:

Wouldn't you love to have the body of a movie star without spending countless hours working out to get there?

In The 30-Minute Celebrity Makeover Miracle,the top Hollywood trainer and Weekend Today fitness expert Steve Zim shows you how to sculpt a phenomenal physique faster and easier than you ever thought possible. In just thirty minutes a day, three times a week, Zim's revolutionary combined cardio and weight-training program will help you ramp up your metabolic rate, burn fat faster than conventional workouts, and produce the body of your dreams in no time. You'll begin to see results after just one week.

Zim shares the celebrity training secrets that have helped his Hollywood clients get in shape for the camera and the red carpet. Once you put his powerful plan into action, you'll be ready for your own closeup. His approach really works, and it doesn't require lots of money or an army of trainersjust a bit of time and effort. Zim shows you how to put together the three crucial pieces of the celebrity makeover program:

Strength Training: You'll learn how to get focused, do the right exercises with the right form, lift the right weight, work all your muscle groups, and stay challenged. Over 100 photographs and clear, easy-to-follow instructions show you how.

Cardio Conditioning: You'll find out how to integrate cardio with to build endurance. No more mind-numbing marathon cardio sessions! You'll incorporate walking, jogging, and lunging into your workouts to strengthen your heart and vary your routine.

Nutrition: Zim's easy-to-follow nutrition plan will fuel your celebrity-style fitness transformation. He teaches you the tricks he uses during makeovers to help you lose weight without starving yourself or feeling deprived. You'll learn how to make the most of the calories you eat without measuring or counting and how to use the glycemic index to optimize the fat-burning capabilities of your body.

With a full ten-week program of Celebrity Makeover Miracle workouts for women and men plus nutrition guidelines, sample menus, and more, you've got all the tools you need to transform yourself into a leaner, stronger, and more fit youwith an A-list body and the confidence to match. Zim's program has worked for thousands of clients. It can work for you, too!

Key words:
New books, 30-Minute Celebrity Makeover Miracle, Steve Zim, Wiley, fitness, weight loss, Strength Training, Cardio Conditioning, weight training, Nutrition

Do you have any comments on this new book?
Post them below!

How Not to Look Old -- New Book

2008-02-07T10:35:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for possible discussion here (no endorsement implied):

How Not to Look Old:
Fast and Effortless Ways to Look 10 Years Younger,
10 Pounds Lighter, 10 Times Better
by Charla Krupp (Hardcover - Jan 2, 2008)

Book Description provided by the Publisher (Springboard Press):

Forget getting older gracefully -- This is the beauty and style bible every woman has been waiting for! HOW NOT TO LOOK OLD is the first--ever cheat sheet of to-dos and fast fixes that pay-off big time -- all from Charla and her friends, the best hair pros, makeup artists, designers, dermatologists, cosmetic dentists and personal shoppers in the biz.

Packed with eye-opening details on hair color, brows, lipstick, wrinkle-erasers, jeans, shapewear, jewelry, heels, and more, the book speaks to every woman: from low maintenance types who don't want to spend a fortune or tons of time on her looks to high maintenance women who believe in looking fabulous at any price. There's also too-old vs. just-right before and after photos, celebrity examples of good and bad style, shopping lists of Charla's brilliant buys in fashion and beauty products, coveted addresses of "Where the top beauty pros go," fun sidebars -- and more. Known to national audiences from her ten years on NBC's Today show, style expert Charla Krupp dishes out her secrets in this "ultimate" to-do list for looking hip and fabulous -- no matter what your age.

About the Author
Charla Krupp lives in New York City.

Key words:
New books, How Not to Look Old, Charla Krupp, Springboard Press, beauty, women, anti-aging, makeup, dermatology, cosmetic dentistry, hair color, style expert, brows, lipstick, wrinkle-erasers, jeans, shapewear, jewelry, heels

Do you have any comments on this new book?
Post them below!

Ageless Memory: Secrets for Keeping Your Mind Young Forever -- New Book

2008-02-06T10:42:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for possible discussion here (no endorsement implied):

Ageless Memory:
Secrets for Keeping Your Mind Young Forever
- From the World's Foremost Memory Expert
by Harry Lorayne (Hardcover - Jan 1, 2008)

Book Description provided by the Publisher (Black Dog & Leventhal Publishers):

The world's foremost memory expertand mega-bestselling authorproves that memory CAN get better with age, using his foolproof system for sharpening the mind, improving concentration, and attaining a truly "superpower" memory.

Completely practical and easy to use, Harry Lorayne's unique memory system can be put into practice immediatelyfor a better memory the very same day you open the book and start to read. With this one book, specially geared for those of us past 50, we learn to:

• Recall names and faces, even years later

• Never miss an appointment or misplace keys, glasses, valuables, etc

• Give speeches without notes and learn foreign words and phrases easily

• Memorize long lists of items, huge numbers, quotations, Bible verses, and all kinds of facts and figures

• And (most important when we age) regain the confidence that comes with having a sharp, active mind.

Harry Lorayne has been honing and teaching his memory systems for 40 years. Ageless Memory is the culmination of his life's work, specially tailored to our needs as we age and encompassing all of the many ways we can use a better memory every day.

Key words:
New books, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, anti-aging, anti-ageing, rejuvenation, life-extension, immortality, Ageless Memory, Young Forever, Harry Lorayne, Black Dog and Leventhal Publishers, memory, sharp mind, concentration

Do you have any comments on this new book?
Post them below!

Naomi's Guide to Aging Gratefully: Facts, Myths, and Good News for Boomers -- New Book

2008-02-05T07:42:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion:

Naomi's Guide to Aging Gratefully:
Facts, Myths, and Good News for Boomers
by Naomi Judd (Paperback - Jan 1, 2008)

Book Description provided by the Publisher (Simon & Schuster):

Naomi Judd has been called "The Face of the Boomer Generation." At 78 million strong, boomers have become America's largest demographic. In Naomi's Guide to Aging Gratefully, she debunks society's harmful myths about aging and finds more meaningful ways we can define ourselves so we can enjoy (rather than dread) getting older.

Freedom is the focus, and there's no better time than now to free yourself from untrue and outdated ideas about your own potential. Naomi is full of fresh ideas to help readers look at their futures in a whole new way. The aging process, as Naomi shows, is an opportunity for new experiences, original routines, and more contentment than ever before.

Naomi offers tips on finding simplicity, streamlining possessions, disengaging from "energy vampires," and discovering the most effective ways to support your life force and boost your energy. Each chapter includes vital new health information and proactive lifestyle suggestions for your body, mind, and spirit. Naomi has a solution-oriented approach to everything from beauty tips to getting in sync hormonally with bioidentical HRT. She also offers wisdom on dealing with grief as well as enlightening ideas on how to recognize and enjoy your own uniqueness no matter how old you are.

Packed with personal anecdotes, commentary from celebrity friends and data from renowned doctors, and plenty of Naomi's own special brand of lemonade-out-of-lemons wit and wisdom, Naomi's Guide to Aging Gratefully encourages readers to believe that it's never too early or too late to enter an important new chapter in their lives and embrace opportunities to become their happiest ever.

Key words:
New books, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, anti-aging, anti-ageing, rejuvenation, life-extension, immortality, Naomi's Guide, Aging Gratefully, Naomi's Guide to Aging Gratefully, Naomi Judd, Simon & Schuster, bioidentical HRT, HRT, hormone replacement therapy.

Do you have any comments on this new book?
Post them below!

Ten Years Thinner -- New Book by Dr. Christine Lydon

2008-02-04T08:20:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion:

Ten Years Thinner
by Christine Lydon (Hardcover - Jan 2008)

Book Description provided by the Publisher (Da Capo Lifelong Books):

A doctor-developed, amazingly simple, six-week eating and exercise program for the body you've always dreamed of having.

What if you could have slimmer hips, firmer thighs, flatter abs, more defined arms, and clearer, younger-looking skin in just six weeks? Based on years of her groundbreaking research and four clinical trials, Dr. Christine Lydon has developed an innovative diet and exercise regimen to burn fat and alter one's body chemistry, resulting in rapid, dramatic results that you will begin to see and feel within the first week.

Governed by ten simple dietary guidelines and ten easy, at-home exercises, Ten Years Thinner emphasizes healthy eating from protein, carbohydrate, and fat sources and demands only twenty to twenty-five minutes of hand-weight exercises a day. There is no calorie counting, messy measuring, or complicated points to calculate; the program requires very little initial physical fitness and promises no more boring and time-consuming cardio workouts. With more than thirty-five delicious recipes and sixty-five easy-to-follow exercise photos, Ten Years Thinner is a simple, sustainable road map to the physique you've always dreamed of having!

Information about the Author provided by the Publisher (Da Capo Lifelong Books):

Christine Lydon, M.D., is a Yale-educated physician, a freelance health writer, and an internationally recognized fitness model. She lives in British Columbia, Canada.

Key words:
New books, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, anti-aging, anti-ageing, rejuvenation, life-extension, immortality, Christine Lydon, eating program, exercise program, diet, exercise, exercises, dietary guidelines, recipes

Do you have any comments on this new book?
Post them below!

Foods That Combat Aging: The Nutritional Way to Stay Healthy Longer

2008-02-03T06:05:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book for discussion:

Foods That Combat Aging: The Nutritional Way to Stay Healthy Longer
by Deborah Mitchell (Mass Market Paperback - Dec 26, 2007)

Book Description provided by the Harper Publisher:

While it is impossible to stop the passage of time, there are ways to prevent it from taking its toll on your appearance and your healthwithout resorting to injections and painful, expensive plastic surgery. The secret is in the foods you eat every day! The right diet can renew your energy; help you to maintain smooth, clear skin and a youthful glow; and actually add years to your life. This remarkable handbook will be your Fountain of Youthproviding meal plans, delicious recipes, and essential information that will enable you to turn back the clock and get a fresh and healthy new start on life!

Your indispensable guide to looking and feeling younger:
-- An easy-to-use nutrition counter covering more than 3,000 foods, broken down by their anti-aging nutrients
-- Mouth-watering recipes to revitalize the body and soul
-- How to shop, how to eat, what to look for to achieve optimum health and maximize your quality of life in later years
-- And much more!

Information about the Author provided by the Harper Publisher:

Deborah Mitchell is a medical writer and journalist specializing in natural medicine and nutrition topics. Her articles have appeared in professional journals as well as national consumer magazines. She has authored or co-authored nine books about various health topics, including The Natural Health Guide to Headache Relief, The Dictionary of Natural Healing, Natural Aphrodisiacs, and The Broccoli Sprouts Break-through. Ms. Mitchell lives and works in Tucson, Arizona.

Key words:
New books, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, anti-aging, anti-ageing, rejuvenation, life-extension, immortality, Foods, Nutrition, Recipes, nutrition counter, Deborah Mitchell, Foods That Combat Aging

Do you have any comments on this new book?
Post them below!

The Official Anti-Aging Revolution: Stop the Clock, Time is on Your Side for a Younger, Stronger, Happier You

2008-02-02T06:44:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Here is a new book, which may provoke at lot of further hot debates on a contentious topic of anti-aging medicine:

The Official Anti-aging Revolution: Stop the Clock, Time is on Your Side for a Younger, Stronger, Happier You
by Ronald Klatz, M.D., and Robert Goldman, M.D., Ph.D. (Paperback - Dec 20, 2007)

Here is an official book description and information about the authors, provided by the Publisher (Basic Health Publications):

Book Description
With medical information doubling every three and a half years, life spans of 110 to 125 years may soon be a reality. Physicians Ronald Klatz and Robert Goldman, pioneers in this brave new world of anti-aging medicine, combine cutting-edge research and the latest medical breakthroughs on longevity, with practical ways for integrating this information into readers's daily lives-how they can live longer, better, and healthier-to create the most comprehensive book on life extension in print today. This book offers a clear understanding of the biological processes involved in aging, the ten key body systems where decline first begins, and the culprits largely responsible for tipping the clock: vitamin and mineral deficiencies and diminishing hormone levels. Readers will learn how to weigh the pros and cons of hormone therapy, naturally stimulate their hormone production, replenish their nutrient stores, strengthen their immune system, nourish their body, burn fat and build lean muscle, revitalize in their sleep, and maintain a youthful mind and spirit. Featuring a longevity test that readers can use to identify how old or young they really are, and the personal life-extension programs of more than two dozen anti-aging specialists. "The Official Anti-Aging Revolution" is the essential resource for anyone who wants to learn how their bodies work, how they age, and what they can do about it.

About Authors
Dr. Ronald Klatz is one of the world's foremost authorities on preventive/longevity medicine. He is senior editor at Longevity magazine, founder and president of the American Longevity Research Institute, co-founder of the National Academy of Sports Medicine, and founder and president of the American Academy of Anti-Aging Medicine, as well as author of man books and articles. Dr. Robert Goldman is-along with being a scientist, surgeon, inventor, researcher, entrepreneur, and author-a former world-champion strength athlete, holding more that twenty world records. He is recognized as a world expert on drug testing and anabolic steroids, and has helped establish international standards in these areas.

Delaying Brain Aging through Dietary Supplements, Mental Exercises, and 'Healthy' Foods

2008-01-15T16:06:00.000-08:00

See also:
-- 'Longevity Science' blog
-- 'Books Forum' blog

Greetings,

Recently I have come across a new popular book written by a medical doctor, which suggests a combination of dietary supplements, mental exercises, and 'healthy' foods designed to:

-- Strengthen memory

-- Sharpen focus

-- Speed reaction time

-- Lift brain fog

-- Alleviate hot flashes

-- Preserve hearing

-- Eliminate migraines

-- Prevent brain aging

-- Fight depression

(cited from the book back-cover).

Obviously the claim to "prevent brain aging" sounds as an overkill, but still it may be interesting to hear from the experts here, and those people who have already read this book, whether there are some good practical suggestions there to follow.

The book also suggests a low-carb diet for each of the seven days a week, with non-overlapping menus for breakfast, lunch, snack, and dinner (see pages 87-93 at http://tinyurl.com/2t6jcv ).

Therefore, it may be interesting to hear from the knowledgeable people here, whether there are some good reasons for switching to low-carb diet and permanent ketosis.

Thank you!

-- Leonid Gavrilov, Ph.D.

P.S.: Here is some additional information about this book:

The Brain Trust Program: A Scientifically Based Three-Part Plan to Improve Memory, Elevate Mood, Enhance Attention, Alleviate Migraine and Menopausal Symptoms, and Boost Mental Energy
by Larry McCleary, M.D., Perigee Trade; 1 edition (September 4, 2007)

Christmas Pictures and Gifts

2007-12-19T10:19:00.000-08:00

Merry Christmas and a Happy New Year to you!

Here are some nice Christmas pictures for you to enjoy -- you are most welcome to drop a comment below, which particular pictures do you like the most.

You can get a bigger size of these pictures just by clicking on them (and also get some new fresh ideas on possible Christmas gifts if you wish).

Enjoy!

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Eva Fraser's Facial Workout (Penguin Health Care & Fitness)

Вторая рабочая конференция компании «МИТОТЕХНОЛОГИЯ»

2007-09-12T06:46:00.001-07:00

Source:
Newsletter of the Gerontological Society of the Russian Academy of Sciences, 2007, July-August issue, page 6.

Вторая рабочая конференция компании «МИТОТЕХНОЛОГИЯ»

В «Вестнике Геронтологического общества РАН» (№ 3-4 (102-103) за март-апрель 2007 г. мы сообщали о первых результатах наиболее масштабного из отечественных биотехнологических проектов. Напомним, что речь идет о финансируемом О.В. Дерипаской проекте компании «Митотехнология», целью которого является создание средства контроля патологий, связанных со старением. Руководит проектом академик РАН В.П. Скулачев. Основная идея проекта была описана в предыдущей публикации. Суть ее в использовании ионов Скулачева – органических гидрофобных катионов, которые, специфически накапливаясь в митохондриях, подавляют наиболее активные очаги свободнорадикального окисления. Важно при этом, что в других частях клетки концентрация ионов Скулачева ничтожна, и они не оказывают заметного влияния на полезные клеточные процессы.

С 27 по 28 августа в Москве (МГУ) проходила вторая рабочая конференция, тема которой была сформулирована руководством проекта как «От Homo sapiens к Homo sapiens discatenatus» Последнее словосочетание можно перевести как «человек разумный раскованный». Использовать это достаточно амбициозное название позволили результаты комплексных испытаний наиболее перспективного из синтезированных в ходе проекта препаратов – SkQ 1. В этом году на формулу препарата, представляющего собой бинарную молекулу, в которой трифенилфосфоний соединен с одним из природных хинонов, был получен российский патент. Поданы заявки еще на 8 патентов. Также была опубликована международная заявка, что является необходимым условием подтверждения приоритета российских ученых.

Состав докладчиков был весьма представительным. Особенно хочется отметить участие в конференции наших соотечественников, работающих в мировых научных центрах: Кима Льюиса (Northeastern University), Натальи и Леонида Гавриловых (University of Chicago), Алексея Рязанова (UMDNJ-Robert Wood Johnson Medical School) и многих других.

Обсуждение полученных к лету 2007 года результатов было одной из главных задач конференции. Важнейшим практическим результатом стало получение разрешения на наружное применение SkQ1. Кроме того подана заявка в Минсельхоз РФ на капли SkQ1 как лекарство от глазных болезней животных. Эффективность такого применения препарата подтверждена клиническими испытаниями. Научные исследования показали способность SkQ1 корректировать самые разные патологии, связанные со старением. Прежде всего, испытания геропротекторного действия вещества подтвердили его способность продлять молодость лабораторных мышей. Напомним, что с точки зрения геронтологии молодость – это период, когда вероятность смерти животного не увеличивается с возрастом. У стандартных для таких исследований мышей этот период продолжается около 200 дней, у мышей, получавших SkQ1 он увеличивается до 400 дней.

Уменьшение зависящей от возраста смертности проявляется и в подавлении ряда распространенных старческих заболеваний. Испытанный учеными препарат тормозит ретинопатии (болезни сетчатки), увеит и катаракту и обращает их развитие; тормозит глаукому; уменьшает зону инфаркта миокарда; снимает сердечную аритмию; уменьшает зону инсульта; спасает от инфаркта почки; тормозит дегенерацию тимуса, развитие лимфом и некоторых других видов рака у животных, тормозит потерю половой мотивации самцов, предотвращает нарушения полового цикла самок.

Одной из наиболее интересных находок стало обнаружение способности SkQ практически полностью подавлять развитие остеопороза у линии (породы) крыс, генетически предрасположенных к этому заболеванию. По мнению врачей-практиков уже одно это, при воспроизведении эффекта для человека, способно оправдать средства, вложенные в проект. Отметим также, что все вышеназванные эффекты вызываются дозами, в сотни тысяч раз меньшими, чем стандартные клинические дозы антиоксидантов, а, следовательно, будущие лекарства на основе ионов Скулачева будут гораздо безопаснее в плане побочных эффектов.

Другой задачей конференции было обсуждение вопроса, вынесенного В.П. Скулачевым в подзаголовок пленарного доклада: «Существуют ли генетические программы полезные для сохранения, изменчивости и экспансии генома, но вредные для индивида?» Сам Владимир Петрович считает старение результатом специальной генетической программы, «созданной» природой для ускорения эволюции. Хочется отметить, что в рамках конференции были предоставлены широкие возможности для критики этой теории. Слово получили специалисты самых разных направлений, считающих старение результатом накопления случайных ошибок. Подводя итоги дискуссии можно констатировать, что высокая эффективность SkQ, формула которого была предсказана Скулачевым именно на основе его теории «феноптоза», является на сегодняшний день самым сильным аргументом в поддержку идеи запрограммированного старения. И этот практический аргумент весьма сложно опровергнуть теоретическими рассуждениями.

Рассмотрению комплекса теоретических и практических проблем современной геронтологии был посвящен доклад проф. В.Н. Анисимова. Автор обратил внимание участников проекта на комплексный характер феномена старения. Сложность, задействованных в его развитии процессов определяет то, что для достижения реального успеха, применение любых средств замедляющих старение должно сопровождаться радикальным изменением образа жизни людей. В частности, последние исследования показали, что даже незначительные нарушения естественного режима освещенности ведет к росту числа онкологических заболеваний.

Работа над проектом ведется в десятках лабораторий, расположенных в нескольких странах. Их эффективная координация не была бы возможной без использования специально разработанной ведущими отечественными специалистами автоматизированной системы управления. Благодаря ей руководитель проекта не выходя из своего кабинета в МГУ может получать свежие научные данные из лабораторий фактически в режиме “on line”. Однако никакие кибернетические системы не могут заменить непосредственного общения ученых. Самое важное при этом обеспечить единство коллектива, не подавляя творческой свободы его членов. Здесь можно вспомнить слова Отто Гана, одного из ведущих участников нацистского ядерного проекта. Узнав об успехах американцев в разработке атомной бомбы, он сказал: «Такое сотрудничество было бы невозможно в Германии. Каждый из нас старался бы доказать, что работа другого не имеет значения».

Результаты работы второй рабочей конференции проекта компании «Митотехнология» показали, что при желании, на российскую почву можно перенести не только передовые научные технологии, но и (что, наверное, более важно) передовой стиль руководства, который собственно и позволяет формировать команды единомышленников, способные решать творческие задачи.

Консультант проекта компании «МИТОТЕХНОЛОГИЯ», к.б.н. В.А. Чистяков

Conference program (in Russian)

2007-08-17T10:40:00.000-07:00

Конференция
«От Homo sapiens к Homo sapiens discatenatus»
(27-28 августа, 2007, МГУ, Воробьевы Горы,
лабораторный корпус Б, ауд. 221)

27 августа
Председатель А.М. Оловников
А. 10.00-11.00 Вводная лекция. В. Скулачев. Существуют ли генетические программы, выгодные для сохранения, изменчивости и экспансии генома, но вредные для индивида?
11.00-11.30 Дискуссия
Б. Острый феноптоз.
1. 11.30-12.00 К. Льюис. Феноптоз бактерий.
12.00-12.30 Перерыв
Председатель К. Льюис
2. 12.30-13.00 Ф. Северин. Феноптоз дрожжей.
3. 13.00-13.30 М. Мошкин. Феноптоз у животных: гибель самцов сумчатых мышей после гона и другие примеры.
4. 13.30-14.00 Д. Зоров. Антифеноптическая активность SkQ при инфаркте почки и инсульте.
14.00-16.00 Перерыв
В. Старение как медленный феноптоз.
Председатель В.Н. Анисимов
1. 16.00-16.30 А.Оловников. Можно ли создать долгоиграющую мышь? Геном и парагеном. Парагеном – материальный носитель программы продолжительности жизни.
2. 16.30-17.00 В. Голуб. Зимняя спячка и скорость индивидуального развития.
3. 17.00-17.30 Н. Гаврилова. Летаргия, зимняя спячка и старение.
4. 17.30-18.00 А. Рязанов. eEF2-киназа: фермент, ускоряющий старение.
5. 18.00-18.30 К. Храпко. Митохондриальные гипотезы старения.

28 августа
Председатель Б.В. Черняк
Г. Pro и contra
1. 10.00-10.30 Л. Гаврилов. Старение: теория надежности и концепция феноптоза.
2. 10.30-11.00 И. Попов. Польза и вред эволюции.
3. 11.00-11.30 А. Рязанов. Старение и апоптоз.
4. 11.30-12.00 П. Чумаков. Анти- и прооксидантные свойства белка р53 и его роль в старении.
12.00-12.30 Перерыв
Председатель А.Г. Рязанов
5. 12.30-13.00 А. Хохлов. Pro и contra в гипотезе о старении как программе.
6. 13.00-13.30 В. Анисимов. Горячие точки современной геронтологии.
7. 13.30-14.00 А.Кондрашов. Могла ли эволюция создать генетические программы вредные для индивида?
8. 14.00-15.00. Общая дискуссия

Longevity Secrets of Academicians (Izvestiya - Nauka)

2007-08-16T13:28:00.000-07:00

A Story published in the major Russian newspaper:

http://www.inauka.ru/analysis/article77040/print.html

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http://www.inauka.ru/
СОВМЕСТНЫЙ ПРОЕКТ АКАДЕМИИ НАУК РФ И ОБЩЕНАЦИОНАЛЬНОЙ ГАЗЕТЫ "ИЗВЕСТИЯ" -->

На главную страницуИЗВИЛИНА ДЛИНОЮ В ЖИЗНЬ: В ЧЕМ СЕКРЕТ ДОЛГОЛЕТИЯ НАШИХ АКАДЕМИКОВ
Сергей ЛЕСКОВ
Темы дня: • Теория внеземного происхождения жизни получила новое подтверждение • Биологи нашли ответ на генную "загадку 1%" • Создается самолет, не имеющий ничего общего с обычными лайнерами • Создана "дикая" дорожка для активации скрытых возможностей мозга • Ученый доказал возможность путешествия во времени • Почему войны во льдах Арктики не будет • Россияне первыми дошли на Северном полюсе до дна-->Один из непреложных законов цивилизации во все времена и у всех народов - уважение к старикам. Речь сейчас не о гуманной поддержке тех, кто в преклонном возрасте стал слабее. Человек, выбирая решение, прислушивается к мнению старших по возрасту. Синклиты старейшин в том или ином виде существовали и существуют в любом обществе. Как бы мы ни критиковали Академию наук, она тоже является советом старейшин в современном виде. На собраниях РАН, если отвлечься от прений, бросается в глаза, что это собрание российских аксакалов, которые в большинстве своем бодры и телом, и разумом. И возникает вопрос: нет ли зависимости между здоровьем человека и его интеллектом? Может быть, лучший способ сохранить здоровье - усердно учиться и часто думать? Терпеливые живут дольше В вопросе о зависимости между интеллектом и здоровьем надо избежать хитрых логических ловушек и отказаться от ряда соблазнительных аргументов. Первое - обойтись без имен. Отдельные примеры ничего не решают. Платон был гений мысли и олимпийский чемпион. Стивен Хокинг - тоже гений, но полный инвалид. Корректным может быть только статистический анализ. Кстати, известно, что у 30-50% долгожителей в роду встречались долгожители. Но сказать, что на первом месте генетическая предрасположенность, опять же трудно, потому что в семье сохраняется образ жизни и среда обитания... И второе - не надо путать причину со следствием. Умные люди ведут более здоровый образ жизни - это и дураку ясно. Кроме того, есть профессии, успех в которых зависит от возраста. Кто выживает - тот идет дальше. Возраст -выталкивающая сила к признанию. В США самая высокая продолжительность жизни у членов Верховного суда, которыми изначально становятся почти старцы. Исследований не было, но, уверен, еще выше средний возраст у иерархов церкви. Чемпионы среди чемпионов - римские папы и патриархи, из чего вовсе не следует, что святость и безгрешие напрямую связаны с долгожительством. Высокий средний возраст членов Академии наук тоже отчасти связан с тем, что избирают в нее не рьяных кандидатов наук, а тех, кто пережил конкурентов. Важно и то, что все эти звания - пожизненные, а самым важным стимулом к жизни, если вспомнить данные о том, что толкает людей к эвтаназии, являются востребованность и самостоятельность в пожилые годы. У дураков хилая грудь 30 лет назад ученые Гарвардского университета взяли под контроль группу из 700 семилетних детей. Было обследовано здоровье и одновременно проведен тест на умственное развитие. Наблюдения не прерывались, и недавно были обнародованы результаты второго осмотра. Дети, показавшие в 7 лет высокие умственные способности, во взрослом возрасте отличались более крепким здоровьем. Напротив, те, кто в первом классе не блистал умом, выросли хилыми. И уж тем более будущему академику не помешает быть здоровым: одни нагрузки в аспирантуре чего стоят. Интересен список болезней у людей с неблестящим интеллектом: сахарный диабет, астма, рак и сердечно-сосудистые заболевания. Впрочем, мне кажется, что и для Невтонов список такой же. И не надо научный огород городить, чтобы понять, что умные дети дальше пойдут по жизни, получат лучшее образование, более оплачиваемую работу и хорошее медобслуживание. Богатые свое драгоценное здоровье обычно не транжирят, а стерегут всяческими способами, в том числе избегая вредных привычек. Чтобы устранить этот недостаток, масштабное исследование провел Британский совет. Под контроль была поставлена 1 тысяча человек из разных социальных групп и профессий. Выяснилось, что смертность людей, которые всю жизнь постоянно работают головой, в 4 раза ниже по сравнению с теми, чей мозг не испытывал особой нагрузки. Ученые подчеркивают: важна постоянная интеллектуальная нагрузка, а не просто высокий IQ, который дается каждому природой. Но кто-то возразит: можно работать головой, быть здоровым - и дать дуба в один момент. Самый неоспоримый показатель здоровья - долгожительство. В 2007 году самые авторитетные издания New York Times, Washington Post, New Scientist уделили много места результатам, быть может, самой интересной и полной работы о факторах, которые влияют на продолжительность жизни. Эта работа сделана в университете Чикаго по программе Национального института здоровья США российскими учеными Леонидом и Натальей Гавриловыми, которые 10 лет назад уехали из России и обосновались за границей. Методологически это самый чистый из всех известных эксперимент, поскольку Гавриловым удалось исключить социальный фактор, искажавший все прежние результаты. Российские научные эмигранты обратили внимание на то, что сами американцы по привычке упускали из виду: в интернете в открытом доступе выложены подробнейшие данные всех переписей населения США, которые проводятся каждые 10 лет. Кроме того, в ход пошли результаты антропометрических исследований, выполненных во время Первой мировой войны поголовно среди американцев до 30 лет. Мама должна быть молодая В июле 2007 года Леонид и Наталья Гавриловы приехали с докладом в Санкт-Петербург на крупную международную конференцию по геронтологии. Затем побывали в МГУ, где договорились о совместных работах с командой академика Владимира Скулачева, который ведет изнурительную и захватывающую погоню за геном смерти. О работе четы Гавриловых "Известия" узнали из первых рук. Итак, чем по статистике определяется доживаемость человека до 100 лет? Самый важный фактор - возраст матери. Если мама младше 25 лет, у ребенка в 2 раза выше шансов стать долгожителем, чем у братьев и сестер. Порядковый номер ребенка роли не играет, главное - возраст матери. Даже для стариков после 70 лет важно, молода ли в незапамятные года была мама. А вот с возрастом отца статистической зависимости не найдено. Любопытно, что недавнее исследование в европейских королевских домах установило необъяснимую закономерность: у пожилых отцов дочери живут на 4 года меньше. Но это локальный и статистически недостоверный результат. Какие гипотезы? Чтобы выяснить истину, гипотез должно быть много - иначе наука не работает. Может быть, первые яйцеклетки по качеству лучше, чем последующие. У млекопитающих расходуются яйцеклетки по очередности вызревания. В 2005 году сходный результат был получен на мышах: первые яйцеклетки лучше. Это имеет эволюционный смысл - второго шанса получить потомство природа может не предоставить. Есть по другому, правда, поводу английская поговорка - best eggs use first. Хотя и договорились, удержаться трудно: Менделеев был 14-м ребенком в семье, Линкольн и Ленин тоже из многодетных семей. Еще одна версия: чем старше мать, тем больше скрытых инфекций накапливается в ее организме. И это отражается на внутриутробном развитии ребенка, когда запускаются скрытые хронические воспаления. Худоба и жизнь в деревне - залог здоровья Чтобы стать долгожителем, надо следить за фигурой. Статистика утверждает: не важно, нормальный ты или чуть худой, но нельзя быть толстым. Ожирение даже на 10-15% катастрофически снижает шансы стать долгожителем. И еще одна закономерность. Если человек провел детство в деревне, шансов стать долгожителем у него значительно выше. Городские жители обречены на раннюю смерть. Важно подчеркнуть, что эти выводы касаются нынешних стариков, а как сложится жизнь у современных горожан и фермеров, науке неведомо. Ожирение влияет не только на продолжительность жизни, но и на интеллект, что подтверждено работами французских ученых, которые в течение 5 лет исследовали 2200 мужчин и женщин в возрасте от 32 до 62 лет, выполнявших тесты на умственные способности. Люди нормального и худого сложения выполняют 56% теста, а те, кто страдает ожирением, - лишь 44%. Через 5 лет упитанные граждане опустились еще ниже - до 37,5%. У людей с нормальным весом показатели не изменились. Как ни крути, худым быть выгоднее - и ума палата, и живешь дольше. А еще раньше мы установили: если ты умнее и чаще работаешь головой, то и живешь дольше. Цепочка такая выходит: умный - здоровый - худой - столетний. О холостяках, курильщиках и миллионерах Есть много версий о том, какие факторы влияют на продолжительность жизни. Если проверить их беспристрастной статистикой, выясняется, что все это мифы. Холостяки живут столько же, сколько семейные. Рост, если он в пределах нормы, никак не связан с продолжительностью жизни. И вовсе не элита, и не миллионеры формируют ряды долгожителей, а рядовые обыватели. Отрицательным фактором, это доказано точно, является курение. В самом деле, не могу припомнить, кто из наших академиков курит. Кстати, в США страхование жизни для курящих людей происходит по очень жесткому тарифу. Есть на сей счет два исключения: курение показано при болезни Паркинсона. И после 90 лет связь между возрастом и курением стирается, там уж все едино. А вот умеренное потребление алкоголя снижает смертность, и выпивающих академиков я видел в изобилии. Статистически достоверных данных о том, что жизнерадостные люди живут дольше, не имеется, но отсутствие данных не означает, что это не так. Но как иначе - если от жизни нет радости, то зачем жить? Бессмертие для вождя Исследования по геронтологии активно поддерживались в СССР. Сталин создал для профессора Александра Богомольца в Киеве Институт геронтологии. Но ученый умер, когда был моложе своего покровителя, на что Сталин заметил: "Всех обманул, мерзавец!" В 1980-1990-е годы геронтология отошла на задний план и встала чуть не на одну доску с астрологией, из-за чего Гавриловым пришлось искать научный трамплин за границей. Но вовсе не астрологией, а сезонными колебаниями витаминов и инфекций объясняется то, что в США полезнее всего родиться в январе, а хуже всего - в мае. Схожие колебания работают, должно быть, и в России. Впрочем, сейчас в России геронтология вновь на почетном счету. Последняя идея: исследовать старение по моделям теории надежности для машин академика Колмогорова с учетом того, что ребенок может рождаться с исходными дефектами. Самый большой остроумец современности сказал одну умную вещь: что с человеком ни делай, он упорно ползет на кладбище. Но скорость разная и маршруты тоже. И вообще установлено, что люди похожи на вино: некоторые с возрастом превращаются в уксус, другие становятся еще лучше. Думать надо почаще - здоровее будешь.
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Академик Борис Черток: Достижения космонавтики должны восхищать не ученых, а политических лидеров

Сплав академика Фридляндера

Виталий Гинзбург удостоен ордена "За заслуги перед Отечеством" I степени История первая: академик Борис Черток, 95 лет, конструктор космических кораблей Каждый день к 8 утра он приходит на работу в родную Ракетно-космическую корпорацию "Энергия" имени Королева. Или на лекции в МГТУ имени Баумана. Патриарх космонавтики последний из замов Королева. Последний, кто был с главным на "ты", на Байконуре они жили в одном домике. В молодости был загребным в заводской команде по академической гребле. Был высок и поджар. Занимался альпинизмом, водным туризмом. В прошлом году с рюкзаком обошел Соловки. Плавает в Пироговском водохранилище. Курил много, но несколько лет назад по совету врачей бросил. Выпить в хорошей компании под хорошую закуску не прочь и сейчас, что помогает сохранять вкус к жизни. Запоем читает прессу, следит за новинками. Некоторое время назад академик всю ночь, не сумев оторваться, читал роман Дэна Брауна. Академик Черток - заядлый автомобилист, по-прежнему сам за рулем, "ямщиков"», как говорит, не любит. Недавно пересел с "Волги" на "Тойоту". Сыновья и внуки считали, что трудность управления "Волгой" - гарантия его безопасности. Но академик решил осваивать современную технику. Теперь внуки идут на новую хитрость - не меняют сезонную резину, чтобы дед меньше зимой ездил. Свое пристрастие к автовождению академик объясняет тем, что за рулем чувствует себя совершенно свободным. Работает каждый день, потому что работа, как он говорит, является лучшим тренажером духа, тела и мозгов. Черток - замечательный, остроумный собеседник. Особенно интересуется перспективами развития общества и космонавтики в будущем. История вторая: академик Иосиф Фридляндер, 94 года, создатель ядерных центрифуг Каждое утро он приходит во Всероссийский институт авиационных материалов, где проработал всю жизнь. Академик Фридляндер создал алюминиевые сплавы, из которых построены поколения наших самолетов, а также центрифуги для обогащения урана, без чего невозможно получить ядерное топливо для АЭС и материал для атомных бомб. В США так и не удалось создать такие центрифуги. Они отличаются феноменальными характеристиками - на скорости 1500 оборотов в минуту без остановок вращаются по 30 лет. Ирония в том, что создатель центрифуг превосходит их по прочности. В студенческие годы в МВТУ много занимался боксом. Был высок и жилист. Особенно хорош у будущего академика был хук справа. Он и сейчас с воодушевлением вспоминает, как было приятно стоять над рухнувшим на ринг противником. Тренер уговаривал: "Иосиф, брось учебу. Спорт лучше науки. Будешь сильным - никто дураком не назовет". Продолжал заниматься спортом всю жизнь - волейбол, туризм, плавание. В сталинские времена, когда над ним навис арест, по ночам, чтобы успокоиться, на лыжах накручивал десятки километров. Сейчас каждое утро час занимается с гантелями весом в 3 кг. По два часа в день гуляет. Чтобы сохранить ясность мышления, по рецепту академика Фридляндера, надо оставаться оптимистом в любой ситуации. Никогда не курил, но от рюмки в компании по поводу не отказывался. И сейчас академик во время обеда считает полезным выпить бокал красного вина. До сих пор умеет привлечь внимание женщин, обладая особым искусством с блеском в глазах говорить им изысканные комплименты. Подшучивает над собой, что остается завидным женихом, хотя очень давно и счастливо женат. Работы не сторонится, но, напротив, считает, что она дает силы для жизни и делать ее надо с сердцем и душой. История третья: академик Виталий Гинзбург, 91 год, лауреат Нобелевской премии До 85 лет в Физическом институте им.П.Н.Лебедева РАН (ФИАН) вел знаменитые на весь мир теоретические семинары, до сих пор занимается активной общественной работой и агитирует за научное мышление. Спортом никогда не занимался, был к нему на редкость равнодушен. Однажды жена, мастер спорта по плаванию, затащила будущего академика в горы, но ей самой же пришлось нести рюкзак. Всякой физической работы, дома или на даче, будучи по природе теоретиком, он всегда сторонился. Работал только с бумагами, но увлекался идеями настолько, что адреналин в крови, как сам признавался, буквально бурлил. Академик Гинзбург считает, что ему привалило счастье, потому что работа и хобби для него совпали. Единственное исключение: 25 лет подряд проводил отпуск на Ладожском озере, где нашел увлечение, не связанное с физикой, - ловля рыбы на блесну. В 30 лет был высок и строен, как кипарис. Никогда не курил. Но выпить мог с удовольствием и очень много, не пьянея. Любимое блюдо - бутерброды. Напиток - молоко.
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Anti-Aging Doctor Cleared of Wrongdoing in Federal Indictment

2007-08-12T10:33:00.000-07:00

Anti-Aging Doctor Cleared of Wrongdoing in Federal Indictment

Aug 10, 2007 06:11 PM

Well-known Nevada medical oncologist and anti-aging physician, James Forsythe M.D., H.M.D. was cleared today of any wrong doing in a thirty month federal investigation and criminal indictment by the Federal Drug Administration and the U.S. Attorney's office into the use of human growth hormone.

"It was unfortunate that this investigation was ever initiated. Everyone now understands that questioning the use of human growth hormone was terribly misguided, and I am grateful to be vindicated.", says Forsythe.

Dr. Forsythe's attorney Kevin Mirch says not only has justice been served but the FDA has requested that Forsythe author the very first protocols for the use of human growth hormone in the medical community across the nation.

"This is the first time in the history of the FDA that they have asked a doctor in private practice to draw up the guidelines for using a drug," says Mirch, and adds, "This is a complete reversal of their original intentions when they went after my client two years ago."

The 68 year-old Forsythe has been a pioneer in integrative therapies and wellness medicine for more than thirty years. His Century Wellness Clinic and Cancer Screening and Treatment Center of Nevada have drawn thousands of patients from all over the world and have also turned Forsythe into an educator in his own profession.

"There is far too much misunderstanding in the medical establishment as to the efficacy of a number of alternative therapies such as hormone replacement therapy." says Forsythe. "I'm sure this has been a learning experience for the FDA and the federal government and I am looking forward to working with the FDA in educating medical professionals and regulatory officials as to the best uses for human growth hormone.

Source:
http://www.krnv.com/global/story.asp?s=6914840&ClientType=Printable
and
http://www.krnv.com/Global/story.asp?S=6914840&nav=8faO

Bacteria 'do not cut short life'

2007-08-11T07:19:00.000-07:00

Bacteria 'do not cut short life'

The theory that bacteria hasten our death has been questioned by research suggesting living in a sterile world would not boost life expectancy.

It has been thought that the immune system response provoked by even harmless bacteria speeds up the ageing process by using up vital energy.

But a study of fruit flies kept in a bacteria-free environment showed they did not outlive their grubby siblings.

The University of Southern California study appears in Cell Metabolism.

The question is, if it's not bacteria that limit life span, then what is it?
Dr John Tower
University of Southern California

The researchers admit their experiment cannot be replicated in higher organisms, which need bacteria for proper digestion and other functions.

But they said the result in flies still may be relevant to human ageing research.

In both flies and humans, the number of bacteria living on the organism increases with age.

The innate immune response to bacteria is similar in flies and humans, and it loses strength with age in both species.

But the study suggests these factors may have nothing to do with ageing.

False assumptions

Lead researcher Dr Steven Finkel said: "I think a lot of people would just assume that if you're increasing bacterial load in an ageing human, it must be bad.

"It might not just be bad, it just might be. Prior to this study, I would not have thought that."

His colleague Dr John Tower said "It's a surprise.

"Even though the flies were accumulating so much bacteria and a robust immune response to that bacteria, it's not limiting how long the flies live.

"The question is, if it's not bacteria that limit life span, then what is it?"

The researchers compared normal fruit flies to specimens born from eggs washed in antibiotic, raised in an axenic (bacteria-free) environment, and given disinfected food throughout their lives.

A third group of flies was raised with bacteria and disinfected in adulthood.

Samples taken from the flies throughout their life confirmed that the axenically-grown flies stayed free from bacteria, while bacteria counts in the normal flies increased dramatically at they got older.

But all the flies lived for approximately three months.

Lorna Layward, of the Help the Aged biomedical Research into Ageing Programme, said the study was interesting.

But she said: "Humans don't live in a world free of infection - we are bombarded with bacteria every day of our lives.

"We know that the older we become the more vulnerable we are to infection.

"Our immunity declines with age, and with an increasingly ageing society, it is important that we research ways to improve the ability to fight infection."

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/6935037.stm
http://news.bbc.co.uk/2/hi/health/6935037.stm

Published: 2007/08/10 23:06:08 GMT

© BBC MMVII

95% of people get Mononucleosis during their lifetimes

2007-08-10T13:05:00.000-07:00

Don't Kiss and Swell: Managing Mono
'Kissing Disease' Threatens Many College Students Each Fall
By TODD S. WILLS, M.D.
Aug. 8, 2007 —

In coming weeks, a new batch of freshman will set off for their first year of college. Awaiting them will be the stresses of class work, the anxiety of living away from home -- and the promise of new relationships.

But for a few unlucky students each year, the first semester also brings a cold, followed by fatigue that they just can't seem to shake.

Is it too many all-nighters cramming for exams? Too many parties? Not enough coffee?

For most, the answer is probably one of these. But for a few, the explanation may be mononucleosis.

What Is Mononucleosis?
Mononucleosis, also known as "mono" or the "kissing disease," is an infection often associated with teenagers, but it also occurs in children.

As can probably be guessed from its intimate moniker, locking lips with an infected person is the most notorious way to contract this disease -- a feature that makes it a natural scourge of college campuses.

However, children and young adults can also become infected by sharing food or drinks, or even simply through close contact with someone who is infected. For this reason, mononucleosis often spreads within families.

But what is the culprit behind this illness?

Most often this disease is caused by the Epstein-Barr virus, which infects white blood cells and causes a sore throat, swollen glands, fever and fatigue in teenagers. Once a person is infected with Epstein-Barr, the virus stays in their white blood cells for life.

Mono is not a rare disease, as 95 percent of people will get it during their lifetimes. By age of 5, about 50 percent of children in the United States have already been infected.

Unfortunately, since Epstein-Barr stays in a person's cells for life, anyone who has been infected in the past can pass the virus to someone else -- even if they have recovered from mono. Because of this, preventing infection is almost impossible.

The Symptoms
In kids, mono is a very mild disease and is usually mistaken for the common cold. A second wave of Epstein-Barr infection strikes young adults between the ages of 18 and 24 who did not get the infection when they were younger.

This disease pops up frequently on college campuses, where one out of every 200 students gets mono each year.

When teenagers get mono, they get the more serious version of the disease. They may suffer from swollen glands, sore throat, fever and fatigue. Some teens will experience headaches, poor appetite, nausea, vomiting and abdominal pain.

Most of these symptoms go away within two or three weeks, but the accompanying fatigue can last for several months.

Though there is no treatment per se for mono, most people recover without any complications. Antibiotics, however, do not help treat mono and may make matters worse; some even cause an itchy skin rash if taken during an Epsein-Barr infection.

When the 'Kissing Disease' Gets Dangerous
Half of young adults who get mono develop an enlarged spleen, which can cause abdominal discomfort. Doctors can determine through a physical exam if your spleen has become enlarged. The spleen should return to normal size in four to six weeks and cause no long-term problems.

However, a patient with mono needs to be very careful if their spleen becomes enlarged. There is a danger of spleen rupture and internal bleeding if the spleen is injured while enlarged.

For this reason, teens diagnosed with mono must avoid contact sports -- or other activities that carry a risk of trauma -- for about six weeks. A ruptured spleen is a life-threatening emergency that usually requires surgery to remove the spleen and stop the bleeding.

Mono can also cause swelling of the tonsils. This is usually not a problem, but if the swelling is severe, it can obstruct airways to the extent that a person cannot breathe. This is a medical emergency that requires immediate treatment. Sufferers should call 911 or get to the nearest emergency room as soon as possible.

People with immune systems weakened by HIV infection or certain medications must also be aware that they have an increased risk for long-term complications from Epstein-Barr infection. In these people, Epstein-Barr can take advantage of the weak immune system to start growing out of control in white blood cells.

Rarely, Epstein-Barr can also cause lymphoma -- a cancer of white blood cells -- in people who have weakened immune systems.

Many studies have sought a link between chronic fatigue syndrome and Epstein-Barr, but no link has yet been established. Chronic fatigue syndrome may be caused by another, potentially unidentified infection.

Dr. Todd Wills is an assistant professor of infectious diseases and international medicine at the University of South Florida, and is the assistant clinical director of the university's signature interdisciplinary program in allergy, immunology and infectious disease.

Copyright © 2007 ABC News Internet Ventures
http://abcnews.go.com/Health/Germs/Story?id=3455220&page=3

To gain muscle and lose fat, drink milk: study

2007-08-09T11:49:00.000-07:00

To gain muscle and lose fat, drink milk: study

Part of an ongoing study into the impact of drinking milk after heavy weightlifting has found that milk helps exercisers burn more fat.

The study by researchers at McMaster University and published today in the American Journal of Clinical Nutrition, was conducted by the Department of Kinesiology’s Exercise Metabolism Research Group, lead by Stuart Phillips.

The researchers took three groups of young men 18 to 30 years of age – 56 in total – and put them through a rigorous, five-day-per-week weightlifting program over a 12-week period. Following their workouts, study participants drank either two cups of skim milk, a soy beverage with equivalent amounts of protein and energy, or a carbohydrate beverage with an equivalent amount of energy, which was roughly the same as drinking 600 to 700 milliliters of a typical sports drink.

Upon the study’s conclusion, researchers found that the milk drinking group had lost nearly twice as much fat - two pounds - while the carbohydrate beverage group lost one pound of fat. Those drinking soy lost no fat.

At the same time, the gain in muscle was much greater among the milk drinkers than either the soy or carbohydrate beverage study participants. “The loss of fat mass, while expected, was much larger than we thought it would be,” says Phillips, associate professor of kinesiology at McMaster. “I think the practical implications of these results are obvious: if you want to gain muscle and lose fat as a result of working out, drink milk.”

As reported in the first phase of the study, the milk drinking group came out on top in terms of muscle gain with an estimated 40 per cent or 2.5 pounds more muscle mass than the soy beverage drinkers. In addition, this group gained 63 per cent or 3.3 pounds, more muscle mass than the carbohydrate beverage drinkers. “I think the evidence is beginning to mount,” says Phillips. “Milk may be best known for its calcium content in supporting bone health, but our research, and that of others, continually supports milk’s ability to aid in muscle growth and also promote body fat loss. To my mind – with milk being a source of nine essential nutrients – it’s a no brainer: milk is the ideal post-workout drink for recreational exercisers and athletes alike.”

Source: McMaster University
http://www.physorg.com/news105797929.html

Diabetes problems 'vitamin link'

2007-08-08T06:36:00.000-07:00

Diabetes problems 'vitamin link'

A simple vitamin deficiency may be the cause of many of the side effects of diabetes, a study suggests.

Researchers found people with the disease expelled thiamine - vitamin B1 - from their bodies at 15 times the normal rate in a study of 94 people.

The Warwick University team said thiamine helped ward off complications such as heart disease and eye problems, the Diabetologia journal said.

Experts said diet supplements could potentially help people with diabetes.

Supplementing diets could be an effective way of minimising the risk of these complications
Professor Paul Thornalley, lead researcher

It is the first time a deficiency of the vitamin, which is found in meat, yeast and grains, has been identified in people with diabetes.

It has been missed in the past because of the way thiamine levels were measured.

Traditionally, the activity of an enzyme called transketolase in red blood cells has been used to indicate thiamine levels.

But the researchers found that increased activity - usually a sign of high thiamine levels - was also associated with the body's response to deficiency.

Instead, the team measured thiamine levels in blood plasma and found concentrations were 76% lower in people with type 1 diabetes and 75% lower in people with type 2.

Thiamine is key to warding off vascular problems such as kidney, retina and nerve damage as well as heart disease and stroke.

It works by helping protect cells against the effect of high glucose levels.

Trials are now being carried out to see if supplementing diet with thiamine could return levels to normal.

Diets

Lead researcher Professor Paul Thornalley said: "It is early days, but it could have a huge difference.

"Supplementing diets could be an effective way of minimising the risk of these complications."

Matt Hunt, of Diabetes UK, which helped to fund the study, said more research was needed.

But he added: "The study could potentially have very exciting outcomes.

"Around 80% of people with diabetes die of cardiovascular disease and diabetes is the leading cause of blindness in the UK's working age population.

"Therefore, any research that could help must be looked at seriously."

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/6935482.stm

Published: 2007/08/07 23:05:27 GMT

© BBC MMVII

Coffee 'protects female memory'

2007-08-07T08:40:00.000-07:00

Coffee 'protects female memory'

Caffeine may help older women ward off mental decline, research suggests.

French researchers compared women aged 65 and older who drank more than three cups of coffee per day with those who drank one cup or less per day.

Those who drank more caffeine showed less decline in memory tests over a four year period.

The study, published in the journal Neurology, raises the possibility that caffeine may even protect against the development of dementia.

It might be that caffeine could slow the dementia process
Dr Karen Ritchie
French National Institute for Health and Medical Research

The results held up even after factors such as education, high blood pressure and disease were taken into account.

Caffeine is a known psychostimulant, but this study appears to suggest its effects may be more profound.

However, lead researcher Dr Karen Ritchie of the French National Institute for Health and Medical Research warned against jumping to premature conclusions.

She said: "While we have some ideas as to how this works biologically, we need to have a better understanding of how caffeine affects the brain before we can start promoting caffeine intake as a way to reduce cognitive decline.

"But the results are interesting - caffeine use is already widespread and it has fewer side effects than other treatments for cognitive decline, and it requires a relatively small amount for a beneficial effect."

The study, which involved 7,000 women, did not find that caffeine consumers had lower rates of dementia.

Women 'more sensitive'

Dr Ritchie said: "We really need a longer study to look at whether caffeine prevents dementia; it might be that caffeine could slow the dementia process rather than preventing it."

She said it was not clear why the protective effect did not seem to apply to men.

"Women may be more sensitive to the effects of caffeine. Their bodies may react differently to the stimulant, or they may metabolize caffeine differently."

Rebecca Wood, chief executive of the Alzheimer's Research Trust, said that with no cure for Alzheimer's disease yet available, research into possible protective factors was important, particularly as the disease is expected to become more common.

She said: "This study does not suggest that caffeine actually lowers rates of dementia in women, but since memory seems improved, it may be that it is slowing it down.

"However, research over a much longer period is still needed to establish fully what the affects of caffeine are in both men and women and whether it could reduce a person's risk of dementia or slow down its progress."

Dr Susanne Sorensen, head of research at the Alzheimer's Society, said drinking coffee and tea had both been tipped as possible ways of delaying the onset of dementia.

However, she said: "These types of studies are complex because coffee and tea drinking can be linked to so many other social and life style factors."

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/6930114.stm

Published: 2007/08/07 06:45:02 GMT

© BBC MMVII

Obesity 'contagious', experts say

2007-07-26T04:43:00.000-07:00

Obesity 'contagious', experts say

Having a friend, sibling or spouse who is overweight raises a person's risk of being obese too, US researchers say.

They said data on more than 12,000 people suggested the risk was increased by 57% if a friend was obese, by 40% if a sibling was and 37% if a spouse was.

They argued this showed social factors, such as the body sizes of other people, were important in developing obesity.

Experts said the New England Journal of Medicine study was not conclusive as other hidden factors could be to blame.

People come to think that it is OK to be bigger since those around them are bigger
Professor Nicholas Christakis

Researchers at Harvard Medical School and the University of California, in San Diego, looked at data collected over 32 years as part of a heart study.

Participants gave personal information, including their body mass index, and the names of friends who could be contacted.

'Causal relationship'

The authors were able to map social connections including both friends and family members.

The effects were generally larger between people of the same sex.

And their analysis suggested that the links could not be solely attributed to similarities in lifestyle and environment, for example the impact of friends existed even where friends lived in different regions.

The statistics may be meaningful, but in real life this is not very helpful to people who are overweight
Professor Andrew Hill

Author Professor Nicholas Christakis said: "It's not that obese or non-obese people simply find other similar people to hang out with.

"Rather, there is a direct, causal relationship. What appears to be happening is that a person becoming obese most likely causes a change of norms about what counts as an appropriate body size.

"People come to think that it is OK to be bigger since those around them are bigger, and this sensibility spreads."

Moral support

Dr Richard Suzman, director of the National Institute of Aging's Behavioral and Social Research Programme, said the finding could have important implications.

He said: "This seminal study breaks important new ground in showing how social networks may amplify other factors and help account for the dramatic increase in obesity across the [US] population."

Dr Ian Campbell, medical director of charity Weight Concern, said it was no surprise that people who are obese tended to be friends with others who were obese, but that the fact that the link was more important between friends than siblings was "very interesting".

He said this suggested that social factors were even more important than physical ones in obesity.

He added that, on the positive side, if overweight people had friends who were obese, they could offer moral support to help each other lose weight.

'Speculation'

But Professor Andrew Hill, of the University of Leeds, said it was purely speculation to suggest that people's body images change because their friends become obese.

And he said it was important not to forget things which are known as key factors in obesity, such as diet and exercise.

"The statistics may be meaningful, but in real life this is not very helpful to people who are overweight.

"We don't have an understanding of what is really causing the relationship - it might be very complicated."

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/6914397.stm

Published: 2007/07/26 00:29:51 GMT

© BBC MMVII

Hibernation, Aging and Longevity

2007-07-25T09:24:00.000-07:00

Greetings,

I would greatly appreciate an advice from knowledgeable people on the effects of lethargic sleep on human aging and longevity. I have tried to search for scientific literature on this topic, but found mostly studies on the effects of hibernation in animal models (see below, listed in reversed chronological order).

If you know more direct studies and publications on this topic (effects of lethargic sleep on human aging and longevity), please advise by posting a comment here (see the end of this post for comment option).

Thank you!

Selected list of scientific publications on the effects of Lethargic Sleep (Hibernation) on Aging and Longevity

1: A skeletochronological study of age, growth and longevity in a population of the frog Rana ridibunda from southern Europe.
Zoology (Jena). 2007 Jul 10; [Epub ahead of print]
Kyriakopoulou-Sklavounou P, Stylianou P, Tsiora A.
Department of Zoology, Aristotle University of Thessaloniki, Box 134, 541 24 Thessaloniki, Greece.
Age at sexual maturity and longevity in a population of Rana ridibunda from north-eastern Greece were studied by skeletochronology performed on the phalanges. Analysis of the age structure was based on counting the lines of arrested growth (LAGs). Sexual maturity for both sexes arises during the first year or after the first hibernation. Ages ranged from 1 to 5 years (mean=2.96) among 52 males and from 1 to 5 years (mean=3.73) among 56 females. The mean snout-vent length was 69.03+/-12.6mm in males and 82.38+/-13.27mm in females. The difference between the sexes in age and size was significant. Growth of individuals was fitted on The von Bertalanffy model. The growth coefficient (K) was 0.57 in males and 0.54 in females, mainly due to faster male growth between metamorphosis and maturation.
PMID: 17628458

2: Black bear femoral geometry and cortical porosity are not adversely affected by ageing despite annual periods of disuse (hibernation).
J Anat. 2007 Feb;210(2):160-9.
McGee ME, Miller DL, Auger J, Black HL, Donahue SW.
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931,USA.
Disuse (i.e. inactivity) causes bone loss, and a recovery period that is 2-3 times longer than the inactive period is usually required to recover lost bone. However, black bears experience annual disuse (hibernation) and remobilization periods that are approximately equal in length, yet bears maintain or increase cortical bone material properties and whole bone mechanical properties with age. In this study, we investigated the architectural properties of bear femurs to determine whether cortical structure is preserved with age in bears. We showed that cross-sectional geometric properties increase with age, but porosity and resorption cavity density do not change with age in skeletally immature male and female bears. These findings suggest that structural properties substantially contribute to increasing whole bone strength with age in bears, particularly during skeletal maturation. Porosity was not different between skeletally immature and mature bears, and showed minimal regional variations between anatomical quadrants and radial positions that were similar in pattern and magnitude between skeletally immature and mature bears. We also found gender dimorphisms in bear cortical bone properties: females have smaller, less porous bones than males. Our results provide further support for the idea that black bears possess a biological mechanism to prevent disuse osteoporosis.
PMID: 17261138

3: Of bears, frogs, meat, mice and men: complexity of factors affecting skeletal muscle mass and fat.
Bioessays. 2006 Oct;28(10):994-1009. Review.
Shavlakadze T, Grounds M.
School of Anatomy and Human Biology, The University of Western Australia, 6009, Western Australia. sthea@anhb.uwa.edu.au
Extreme loss of skeletal muscle mass (atrophy) occurs in human muscles that are not used. In striking contrast, skeletal muscles do not rapidly waste away in hibernating mammals such as bears, or aestivating frogs, subjected to many months of inactivity and starvation. What factors regulate skeletal muscle mass and what mechanisms protect against muscle atrophy in some species? Severe atrophy also occurs with ageing and there is much clinical interest in reducing such loss of muscle mass and strength (sarcopenia). In the meat industry, a key aim is optimizing the control of skeletal muscle growth and meat quality. The impaired response of muscle to insulin resulting in diabetes, that is a consequence of the metabolic impact of increasing obesity and fat deposition in humans, is also of increasing clinical concern. Intensive research in these fields, combined with mouse models, is reviewed with respect to the molecular control of muscle growth (myogenesis) and atrophy/hypertrophy and fat deposition (adipogenesis) in skeletal muscle, with a focus on IGF-1/insulin signaling. (c) 2006 Wiley Periodicals, Inc.
PMID: 16998828

4: [Chrological and physiological age of the tick Ixodes ricinus females]
Parazitologiia. 2006 Mar-Apr;40(2):132-9. Russian.
Naumov RL.
Changes of the physiological age in 3 groups of the laboratory reared Ixodes ricinus females were investigated over the period of 6-16 months. The longevity was studied in 27 groups of the tick females from a wild population during 2 seasons of the tick activity. Physiological age of the tick females was determined at the beginning of the study and then monthly till the end of the study. It was established that physiological ageing takes place during the life of the tick, and the ageing of different females is carried out non-uniformly. Physiologically young females (of the second physiological age) in the groups of laboratory reared ticks were occurred right up to 11th month after molting (including 4 months of hibernation in a refrigerator). Ticks of the second physiological age were occurred in the groups from wild populations after one or two periods of hibernation. Hence, in natural conditions some females may be physiologically young both in the first and second seasons of the ticks' activity. On the other hand, physiologically old tick females (of the 4th physiological age) appeared in the groups in a month after molting. The supposition is proposed that the tick population is heterogeneous by the rate of the individual ageing. It means that different specimens differ by the rate of consumption of their storage compounds i.e. by the intensity of metabolism. Such difference may be a cause of the variability in chemical conditions in the gut of the tick being the habitat of Borrelia.
PMID: 16755722

5: Food, fertility and longevity.
Biogerontology. 2006 Jun;7(3):139-41.
Holliday R.
Some animals live in environments in which the food supply fluctuates. When it is scarce these animals do not breed, but invest resources into survival until food is again available, and they can reproduce. Under these circumstances the lifespan can be increased, just as it is after calorie restriction. Other animals have a fairly constant food supply, and it is predicted that these would not have an extended life span if subjected to calorie restriction. Hibernation is a natural form of calorie restriction, and in some cases may lengthen lifespan
PMID: 16676135

6: Parathyroid hormone may maintain bone formation in hibernating black bears (Ursus americanus) to prevent disuse osteoporosis.
J Exp Biol. 2006 May;209(Pt 9):1630-8.
Donahue SW, Galley SA, Vaughan MR, Patterson-Buckendahl P, Demers LM, Vance JL, McGee ME.
Michigan Technological University, 1400 Townsend Drive, Houghton, 49931, USA. swdonahu@mtu.edu
Mechanical unloading of bone causes an imbalance in bone formation and resorption leading to bone loss and increased fracture risk. Black bears (Ursus americanus) are inactive for up to six months during hibernation, yet bone mineral content and strength do not decrease with disuse or aging. To test whether hibernating bears have biological mechanisms to prevent disuse osteoporosis, we measured the serum concentrations of hormones and growth factors involved in bone metabolism and correlated them with the serum concentration of a bone formation marker (osteocalcin). Serum was obtained from black bears over a 7-month duration that included periods of activity and inactivity. Both resorption and formation markers increased during hibernation, suggesting high bone turnover occurred during inactivity. However, bone formation appeared to be balanced with bone resorption. The serum concentration of parathyroid hormone (PTH) was higher in the hibernation (P=0.35) and post-hibernation (P=0.006) seasons relative to pre-hibernation levels. Serum leptin was lower (P<0.004) p="0.64)">

7: Hibernating bears as a model for preventing disuse osteoporosis.
J Biomech. 2006;39(8):1480-8. Epub 2005 Jun 21.
Donahue SW, McGee ME, Harvey KB, Vaughan MR, Robbins CT.
Department of Biomedical Engineering, Michigan Technological University, 309 Minerals and Materials Engineering Building, 1400 Townsend Drive, Houghton, MI 49931, USA. swdonahu@mtu.edu
The hibernating bear is an excellent model for disuse osteoporosis in humans because it is a naturally occurring large animal model. Furthermore, bears and humans have similar lower limb skeletal morphology, and bears walk plantigrade like humans. Black bears (Ursus americanus) may not develop disuse osteoporosis during long periods of disuse (i.e. hibernation) because they maintain osteoblastic bone formation during hibernation. As a consequence, bone volume, mineral content, porosity, and strength are not adversely affected by annual periods of disuse. In fact, cortical bone bending strength has been shown to increase with age in hibernating black bears without a significant change in porosity. Other animals require remobilization periods 2-3 times longer than the immobilization period to recover the bone lost during disuse. Our findings support the hypothesis that black bears, which hibernate for as long as 5-7 months annually, have evolved biological mechanisms to mitigate the adverse effects of disuse on bone porosity and strength.
PMID: 15975583

8: The myth and reality of reversal of aging by hormesis.
Ann N Y Acad Sci. 2005 Dec;1057:165-76.
Sonneborn JS.
Department of Zoology & Physiology, University of Wyoming, Box 3663, 16th & Gibbon Street, Laramie, Wyoming 82071, USA. cancun@uwyo.edu
Hormesis is an adaptive response to low doses of otherwise harmful agents by triggering a cascade of stress-specific resistance pathways. Evidence from protozoa, nematodes, flies, rodents, and primates indicate that stress-induced tolerance modulates survival and longevity. "Reality" is that hormesis can prolong the healthy life span. Genetic background provides the potential for longevity duration induced by stress. Senesence, or aging, is generally thought to be due to a different impact of selection for alleles positive for reproduction during early life but harmful in later life, a process called antagonistic pleiotropy (multiple phenotypic changes by a single gene). After reproduction, life span is "invisible" to selection. I propose the revision that mutations selected for survival until reproduction in early life may also extend later life (protagonistic pleiotropy). The protagonist candidate genes for extended life span are hormetic response genes, which activate the protective effect in both early and later life. My revision of the earlier evolutionary theory implies that natural selection of genes critical for early survival (life span until reproduction) can also be beneficial for extended longevity in old age, tipping the evolutionary balance in favor of a latent inducible life span extension unless excess stressor challenge exceeds the protection capacity. Mimetic triggers of the stress response promise the option of tricking the induction of metabolic pathways that confer resistance to environmental challenges, increased healthy life span, rejuvenation, and disease intervention without the danger of overwhelming damage by the stressor. Public policy should anticipate an increase in healthy life span.
PMID: 16399893

9: The tensile strength of black bear (Ursus americanus) cortical bone is not compromised with aging despite annual periods of hibernation.
J Biomech. 2005 Nov;38(11):2143-50.
Harvey KB, Drummer TD, Donahue SW.
Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA.
Black bears (Ursus americanus) may not develop disuse osteoporosis during long periods of disuse (i.e. hibernation) because they may be able to maintain bone formation. Previously, we found that cortical bone bending strength was not compromised with age in black bears' tibias, despite annual periods of disuse. Here we showed that cortical bone tensile strength (166-198MPa) also does not decrease with age (2-14 years) in black bear tibias. There were also no significant age-related changes in cortical bone porosity in black bear tibias. It is likely that the ability of black bears to maintain bone formation during hibernation keeps bone porosity low (2.3-8.6%) with aging, notwithstanding annual periods of disuse. This low porosity likely preserves ultimate stress with aging. Female bears give birth and nurse during hibernation; however, we found no significant differences between male and female tensile material properties, mineral content, or porosity. Our findings support the idea that black bears, which hibernate 5-7 months annually, have evolved biological mechanisms to mitigate the adverse effects of disuse on bone porosity and strength.
PMID: 16115638

10: Phosphorylation of the tau protein sequence 199-205 in the hippocampal CA3 region of Syrian hamsters in adulthood and during aging.
Brain Res. 2005 Sep 14;1056(1):100-4.
Hartig W, Oklejewicz M, Strijkstra AM, Boerema AS, Stieler J, Arendt T.
Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Jahnallee 59, D-04109 Leipzig, Germany. hartig@medizin.uni-leipzig.de
Paired helical filaments formed by the abnormally phosphorylated microtubule-associated tau are a main sign of Alzheimer's disease and other neurodegenerative disorders. The hippocampal CA3 region, a brain region with a high degree of synaptic plasticity, is known to be strongly involved in tau hyperphosphorylation in several neurodegenerative diseases. In addition, reversible tau phosphorylation was observed during hibernation in European ground squirrels. The present study provides data on the tau phosphorylation status in the hippocampus of euthermic Syrian hamsters (Mesocricetus auratus), laboratory animals potentially prone to hibernation. Mossy fibers in the CA3 region of all investigated hamsters were immunostained using an antiserum detecting phospho-serine 199 of tau. A similar staining pattern was obtained with CP-13 detecting phospho-serine 202. In contrast, the monoclonal antibody AT8, recognizing both phosphorylated serine 202 and threonine 205, stained the CA3 region only in old hamsters. These findings implicate an additional link between aging, tau phosphorylation and synaptic plasticity. Furthermore, the presented data allow analyses whether tau phosphorylation is reversible in these facultative hibernators and versatile laboratory animal as it was recently shown for the hibernation cycle of European ground squirrels.
PMID: 16095576 [PubMed - indexed for MEDLINE]

11: Sperm influences female hibernation success, survival and fitness in the bumble-bee Bombus terrestris.
Proc Biol Sci. 2005 Feb 7;272(1560):319-23.
Baer B, Schmid-Hempel P.
Copenhagen University, Institute of Biology, Department for Population Biology, 2100 Copenhagen, Denmark. bcbaer@bi.ku.dk
We present evidence that in the absence of the transfer of male gland compounds in the ejaculate as well as of behavioural male traits, such as mate guarding or harming of females, sperm itself affects female life-history traits such as hibernation success, female longevity and female fitness. Using the bumble-bee Bombus terrestris, we artificially inseminated queens (females) with sperm from one or several males and show that sire groups (groups of brother males) vary in their effects on queen hibernation survival, longevity and fitness. In addition, multiply inseminated queens always had a lower performance as compared to singly inseminated queens. Apart from these main effects, sire groups (in situations of multiple insemination) affected queen longevity and fitness not independently of each other, i.e. certain sire group combinations were more harmful to queens than others. So far, the cause(s) of these effects remain(s) elusive. Harmful male traits as detected here are not necessarily expected to evolve in social insects because males depend on females for a successful completion of a colony cycle and thus have strong convergent interests with their mates.
PMID: 15705558

12: Ageing studies on bats: a review.
Biogerontology. 2004;5(4):211-22. Review.
Brunet-Rossinni AK, Austad SN.
Department of Biological Sciences, University of Idaho, P.O.Box 443051, Moscow, ID 83844-3051, USA. anja.brunet@stanfordalumni.org
Bat biologists have long known about the exceptional longevity of bats (Order: Chiroptera), which is unusual for mammals of such a small size and a high metabolic rate. Yet relatively few mechanistic studies have focused on this longevity. On average, species of Chiroptera live three times longer than predicted by their body size. In addition, bats have other life history traits that are characteristic of large, long-lived mammals such as few and large offspring and slow growth rates. Bats fit the evolutionary theory of ageing, as their extended longevity is predicted by their ability to escape extrinsic mortality through flight and, in some species, hibernation. They also show tradeoffs between longevity and reproduction, as predicted by the disposable soma theory of ageing. From a physiological perspective, bat longevity reportedly correlates with replicative longevity, low brain calpain activity, and reduced reactive oxygen species production. As long-lived and physiologically interesting organisms, bats may prove to be an informative model system for ageing research.
PMID: 15314271

13: Life history, ecology and longevity in bats.
Aging Cell. 2002 Dec;1(2):124-31.
Wilkinson GS, South JM.
Department of Biology, University of Maryland, College Park, MD 20742, USA. gw10@umail.umd.edu
The evolutionary theory of aging predicts that life span should decrease in response to the amount of mortality caused by extrinsic sources. Using this prediction, we selected six life history and ecological factors to use in a comparative analysis of longevity among 64 bat species. On average, the maximum recorded life span of a bat is 3.5 times greater than a non-flying placental mammal of similar size. Records of individuals surviving more than 30 years in the wild now exist for five species. Univariate and multivariate analyses of species data, as well as of phylogenetically independent contrasts obtained using a supertree of Chiroptera, reveal that bat life span significantly increases with hibernation, body mass and occasional cave use, but decreases with reproductive rate and is not influenced by diet, colony size or the source of the record. These results are largely consistent with extrinsic mortality risk acting as a determinant of bat longevity. Nevertheless, the strong association between life span and both reproductive rate and hibernation also suggests that bat longevity is strongly influenced by seasonal allocation of non-renewable resources to reproduction. We speculate that hibernation may provide a natural example of caloric restriction, which is known to increase longevity in other mammals.
PMID: 12882342 [PubMed - indexed for MEDLINE]

14: Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles.
Microsc Res Tech. 2002 Nov 15;59(4):331-4.
Furuyama T, Yamashita H, Kitayama K, Higami Y, Shimokawa I, Mori N.
Department of Molecular Genetics, National Institute for Longevity Sciences (NILS), Aichi, Japan. tfuruyam@nils.go.jp
In C. elegans, insulin-like hormone signal pathway plays a significant role in longevity. In particular, daf-16 gene product is indispensable factor for this lifespan-extension. This signal pathway is critical for dauer formation, which is a similar state to hibernation in mammals. We examined the expression level of mammalian daf-16 homologues, Foxo 1,3, and 4 (FKHR, FKHRL1, and AFX) mRNAs in the rat skeletal muscles during aging and in 30% caloric restricted of ad libitum fed. The expression level of AFX mRNA was significantly higher at 6 and 12 months than at 3 and 26 months, and FKHRL1 expression was significantly higher at 6 months than at 3 and 26 months but FKHR expression showed no significant change with age. We observed a characteristic expression of AFX and FKHR mRNAs to be significantly higher in the second day in caloric restriction by every-other-day feeding than in ad libitum fed. This suggests that caloric restriction may increase the expression of FKHR-family genes and prevent the aging process in the skeletal muscles. Copyright 2002 Wiley-Liss, Inc.
PMID: 12424797 [PubMed - indexed for MEDLINE]

15: Effects of size and temperature on metabolic rate.
Science. 2001 Sep 21;293(5538):2248-51. Erratum in: Science 2001 Nov 16;294(5546):1463.
Gillooly JF, Brown JH, West GB, Savage VM, Charnov EL.
Department of Biology, The University of New Mexico, Albuquerque, NM 87131, USA. gillooly@unm.edu
We derive a general model, based on principles of biochemical kinetics and allometry, that characterizes the effects of temperature and body mass on metabolic rate. The model fits metabolic rates of microbes, ectotherms, endotherms (including those in hibernation), and plants in temperatures ranging from 0 degrees to 40 degrees C. Mass- and temperature-compensated resting metabolic rates of all organisms are similar: The lowest (for unicellular organisms and plants) is separated from the highest (for endothermic vertebrates) by a factor of about 20. Temperature and body size are primary determinants of biological time and ecological roles.
PMID: 11567137

-----------THE END----------------

See also:

"Animals that save energy by hibernation or lethargy, for instance bats and hedgehogs, live much longer than those who are always active. This is particularly obvious in closely related animals. Thus, white-toothed and red-toothed shrews can be differentiated by the presence or lack, respectively, of a state of lethargy for saving energy. White-toothed shrews (capable of lethargy) become much older (4-6 years) than their almost equally large red-toothed relations (2-3 years), who are not capable of lethargy."

Cited from:
"Programmed ageing: the theory of maximal metabolic scope"
EMBO Rep. 2005 July; 6(S1): S14-S19. doi: 10.1038/sj.embor.7400425.
Roland Prinzinger, Chair and Head of the Department of Metabolic Physiology at the Johann-Wolfgang Goethe University, Frankfurt/Main, Germany. prinzinger@zoology.uni-frankfurt.de
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1369273 1369273

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See also:

"Interestingly, some evidence suggests that hibernation retards aging (Lyman et al., 1981; Wilkinson & South, 2002) and certain aspects of the physiological state of caloric restriction resembles hibernation (Walford & Spindler, 1997)."

Cited at p.456 in:
A Critical Evaluation of Nonmammalian Models for Aging Research
Steven N. Austad and Andrej Podlutsky, pp.449-467.
Handbook of the Biology of Aging, 2006

Lyman et al (1981) Hibernation and longevity in the Turkish hamster Mesocricetus bradti. Science, 212, 668-670

Wilkinson G.S. & South J.M., (2002) Life history, ecology and longevity in bats. Aging Cell, 1, 124-131.

Walford R.L.& Spindler S.R., (1997) The response to caloric restriction in mammals shows features also common to hibernation: a cross-adaptation hypothesis. Journal of Gerontology A: Biological Sciences and Medical Sciences, 52, B179-BB183

----------------------------------
Cited from:
http://physrev.physiology.org/cgi/content/full/83/4/1153

Lessons from the differential expression of genes controlling carbon utilization in mammalian hibernators have revealed similarities with hypometabolic states in organisms with well-defined genetics. Similarities among the expression of PDK4 during hibernation, the activation of PDK4 in diabetic (low insulin) rodents (258, 260), and the reduction in glucose-based metabolism due to a defective insulin-like receptor in dormant nematodes (146), suggest a conserved mechanism for the molecular control of carbon utilization in mammalian hibernation and nematode diapause Diapause in the nematode Caenorhabditis elegans is characterized by increased fat accumulation and arrested development resulting in the dauer larva stage. For periods of up to 6 mo dauer larvae do not feed, show no movement, and undergo a reduction in glucose-based catabolism (reviewed in Ref. 206). When environmental conditions become more favorable, as seen with spring emergence in hibernating mammals, dauer larvae will resume development and are nearly indistinguishable from individuals that have not arrested at the dauer stage. Genetic analysis has shown that a protein homologous to the mammalian insulin/insulin-like growth factor (IGF-I) receptor, called DAF-2, is a key player in the switch from a normal life cycle to the arrested dauer stage (146). Dauer larvae formation will occur constitutively when a mutation in the daf-2 gene produces a receptor that is defective in the ligand-binding domain. Hence, the inability of an insulin-like ligand to bind DAF-2 leads to a state of dormancy and metabolic rate depression analogous to hibernation in mammals.
Genetic conservation between insulin signaling in mammals and diapause signaling in C. elegans is also seen early in the dauer signal transduction pathway where mutant age-1 alleles cause a dauer constitutive phenotype. The AGE-1 protein is closely related to a family of phosphatidylinositol 3-kinase p110 catalytic subunits thought to associate with the insulin receptor and provide the next step of the insulin-signaling pathway in mammals (182).

Partial activation of the dauer pathway by various daf-2 and age-1 mutants in C. elegans (reviewed in Refs. 59 and 116) results in an extension of life span similar to that seen in hibernating mammals (166).

A 75% decrease in circulating IGF-I in hibernating golden-mantled ground squirrels (213) suggests a reduction in IGF-I signaling similar to that seen in the long-lived C. elegans mutants. In addition, knock-out mice that are heterozygous null for the IGF-I receptor live 26% longer than their wild-type littermates (130). It is possible that an element of the increased longevity associated with hibernation results from elevated PDK4 activity, which reduces carbohydrate oxidation and thus mimics the life-extending effects of caloric restriction in mammals (251).
Recently, daf-2 mutants have also been shown to confer resistance to hypoxia in C. elegans (215). As with the reversibility of low oxygen consumption during arousal from hibernation in mammals, these hypoxia-resistant mutants (Hyp) fully recover from up to 20 h of extremely low oxygen concentrations (215). Nonetheless, it is interesting that various phenotypes associated with hibernation in mammals are also seen with mutants of a single gene encoding an insulin-like receptor in worms.
The physiological and biochemical changes that occur in mammalian hibernators are similar in some respects to those observed in lower vertebrates and invertebrates that undergo estivation and other forms of dormancy. These include the seasonal deposition of fuel reserves, typically in the form of lipid; the switch from carbohydrate to lipid oxidation during periods of metabolic depression; depression of RNA and protein synthesis and degradation; use of reversible phosphorylation of enzymes and other proteins as means to rapidly control metabolic processes; and evidence of increased oxidative stress and antioxidant defenses in certain tissues (108, 109, 112, 121, 227).

-------------------------
From:
http://www.blackwell-synergy.com.proxy.uchicago.edu/doi/full/10.1111/j.1749-6632.2005.tb06124.x

If, as some contend, reduced metabolic rate leads to the (relative) retardation of aging, then the practice of the classic meditative regimen may indeed be associated with significant retardation of aging and/or extension of life span and health span on the basis of much data on the metabolism-lowering effects of meditation. Of particular interest in this regard are studies by researchers from Stanford,19 Harvard,20 Rockefeller University,21 and other research institutions on the special ability of some long-term, virtuoso yoga practitioners to induce and maintain profoundly lowered metabolic rates during meditation, with reductions ranging from 38–64% below resting levels! Such lowered metabolism is actually within the range of hibernating animals,22 and hibernation has been associated with extended longevity in some studies because of lowered metabolism, according to some investigators23 (although not others24).

Reference 24:

J Gerontol. 1991 Mar;46(2):B47-53.Related Articles,Links

Mammalian aging, metabolism, and ecology: evidence from the bats and marsupials.
Austad SN, Fischer KE.
Department of Organismic and Evolutionary Biology, Harvard University.

This study compared trends in body size, life span, metabolic rate, and ecology of bats and marsupials with those from mammals generally, using a 580 species data base. The linear logarithmic relationship between mammalian body mass and maximum longevity, deleting bats and marsupials, is used as a standard against which to measure life spans of particular mammal groups. Bats have maximum life spans a minimum of 3 times those of nonflying eutherians--a trend resulting from neither low basal metabolic rate, the ability to enter torpor, nor large relative brain size. Marsupials live about 80% as long as nonflying eutherians despite averaging lower basal metabolic rates; similarly, there is no effect of heterothermy or relative brain size. These results directly conflict with predictions of both "rate of living" and brain-size mediated theories of aging. However, they are consistent with an evolutionary theory that posits exceptionally long life spans among mammals with reduced environmental vulnerability.
-------------------------------

Heart survival 'higher in obese'

2007-06-20T08:21:00.000-07:00

Heart survival 'higher in obese'

Obese heart attack and angina patients are more likely to survive after treatment, a study suggests.

Researchers found obese patients were less than half as likely to die in the three years after treatment as patients with a normal body mass index.

The German and Swiss study - involving 1,676 patients and in the European Heart Journal - could not explain why.

And experts warned obese people were more likely to develop heart problems in the first place.

The evidence from our study shows once a coronary event has occurred and been optimally treated, obese patients switch to a more favourable prognosis
Dr Heinz Buettner

The study followed 1,676 patients who were hospitalised with unstable angina or a specific type of heart attack called a non-ST-segment elevation myocardial infarction.

Standard treatment was a coronary angiography to diagnose the extent of the problem, followed by a process to unblock the arteries called coronary revascularisation or a coronary artery bypass graft.

Lead researcher Dr Heinz Buettner said: "Although there is no doubt that people who are overweight, obese and very obese have a higher risk of developing diabetes, hypertension and coronary artery disease, the evidence from our study shows once a coronary event has occurred and been optimally treated, obese patients switch to a more favourable prognosis compared to normal weight patients."

The obese patients tended to be younger than the normal weight patients, and were more likely to be given prescriptions for heart drugs such as statins and beta-blockers on discharge from hospital.

But Dr Buettner said his analysis suggested that neither of these two factors could fully explain the lower mortality rate.

Protective effect

He said it was possible that differences in body chemistry caused by obesity might play a role.

For instance, levels of blood platelets, which can affect clotting, are lower in obese patients, while levels of fat in the heart tissue, which might have a protective effect, are higher.

Another theory is that the higher levels of endogenous cannabinoids in obese people might be key. There is a growing body of evidence to suggest that these chemicals have a protective effect during a heart attack.

Dr Buettner said it was important that obese people made efforts to lose weight.

He said: "Not all patients can be treated with early revascularisation because an acute coronary syndrome always has the risk of sudden cardiac death.

"It is well known that even a modest intentional weight loss can improve or prevent obesity-related cardiovascular risk factors."

June Davison, of the British Heart Foundation, said the study raised more questions than it answered.

"Further research is needed for us to understand the reasons for this link," she said.

"What we are sure of, is that if you are overweight you have a higher risk of developing high blood pressure, coronary heart disease and diabetes in the first place."

Story from BBC NEWS:
http://news.bbc.co.uk/go/pr/fr/-/2/hi/health/6768365.stm

Estrogen-Depression Connection?

2007-06-19T20:55:00.000-07:00

Greetings,

I would greatly appreciate your comments and discussion on a provocative statement, that women's depression in later life is largely caused by estrogen deficiency at menopause. This statement is made in this new book, and if correct, this may suggest a simple approach to depression treatment:

The Estrogen-Depression Connection: The Hidden Link Between Hormones & Women's Depression
by Karen J., Ph.D. Miller and Steven A., Ph.D. Rogers (Paperback - May 2007)

From book description:

"Research has shown a strong connection between estrogen levels and depression throughout a woman's lifetime. We now understand that abrupt hormonal changes can take a toll on women's moods and even cause serious depression. But the good news is that there is a lot women can do to moderate the effect of these changes."

Please post your comments below!:

Nutrition and Disease Prevention

2007-06-03T11:36:00.000-07:00

Greetings,

A new book has been just published in the "Nutrition and Disease Prevention" book series:

Geriatric Nutrition (Nutrition and Disease Prevention)
by John E. Morley and David R. Thomas
http://tinyurl.com/2znwda

Book Description
Drawing from a group of outstanding experts in the field, Geriatric Nutrition ties basic research with clinical practice in a state-of-the-art review of current nutritional thinking. Beginning with an overview on nutrition in older persons, the book addresses nutritional requirements, techniques for the clinical assessment of nutrition in older adults, and the management of undernutrition in nursing homes and assisted living environments. A significant portion of the book covers nutrition recommendations in specific disease states, such as psychological issues, obesity, diabetes, cancer, anemia, and fracture risk. The book also considers multicultural and ethical issues relevant to the sensitive treatment of older individuals.

Key words:
New books, Nutrition, Disease Prevention, Geriatric Nutrition, John E. Morley, David R. Thomas, Health, fitness, health-care for seniors, life-extension, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, obesity, diabetes, cancer, anemia, fracture risk

Hope it helps,

Kind regards,

-- Leonid Gavrilov, Ph.D.
Website: http://longevity-science.org/
Blog: http://longevity-science.blogspot.com/
My books: http://longevity-science.org/Books.html

P.S.: See also the list of 26 new books on aging and longevity, which have become available this month:

http://longevity-science.blogspot.com/2007/06/new-books-for-june-2007.html
and
http://tinyurl.com/2k4jd8

No danger is larger than that related to ageing

2007-06-02T07:30:00.000-07:00

"No danger is larger than that related to ageing"

said the Cuban President Fidel Castro:
http://news.bbc.co.uk/2/hi/americas/6714381.stm

Have a nice weekend :)

New Books for May 2007

2007-05-13T15:27:00.001-07:00

Greetings,

Here is the list of new books on aging and longevity, which have become available this month.

The books are listed in reversed chronological order (the most recent books are listed first):

1. Adult Development and Aging
by Bert Hayslip, Julie Hicks-Patrick, and Paul E. Panek (Hardcover - April 30, 2007)

2. Geriatric Rheumatology, An Issue of Rheumatic Disease Clinics (The Clinics: Internal Medicine)
by Arthur F. Kavanaugh (Hardcover - April 30, 2007)

3. Fostering Social Work Gerontology Competence: A Collection of Papers from the First National Gerontological Social Work Conference
by Catherine J., Ph.D. Tompkins and Anita L., Ph.D. Rosen (Paperback - April 30, 2007)

4. Social Care Challenges for the Ageing in Asia
by Raymond Ngan and S. Vasoo (Paperback - April 30, 2007)

5. Dementia: Metamorphosis in Care
by Claire Biernacki (Paperback - April 27, 2007)

6. Getting Started in A Financially Secure Retirement (Getting Started In.....)
by Henry K. Hebeler (Paperback - April 27, 2007)

7. Handbook of Gerontology: Evidence-Based Approaches to Theory, Practice, and Policy
by James A. Blackburn and Catherine N. Dulmus (Hardcover - April 20, 2007)

8. Brain Aging: Models, Methods, and Mechanisms (Frontiers in Neuroscience)
by David R. Riddle (Hardcover - April 19, 2007)

9. Neurobiology of Epilepsy and Aging, Volume 81 (International Review of Neurobiology.)
by R. Eugene Ramsay, James C. Cloyd, Kevin M. Kelly, and Ilo E. Leppik (Hardcover - April 16, 2007)

10. Healthy Aging & Longevity Third International Conference (Annals of the New York Academy of Sciences)
by Weller Noah J (Paperback - April 15, 2007)

11. Encyclopedia of Health and Aging
by Kyriakos S. Markides (Hardcover - April 13, 2007)

12. Assisted Dying and Legal Change
by Penney Lewis (Hardcover - April 12, 2007)

13. Intersections of Aging: Readings in Social Gerontology
by Jon Hendricks, Elizabeth W. Markson, and Lisa A. Hollis-Sawyer (Paperback - April 10, 2007)

14. Chasing Life: New Discoveries in the Search for Immortality to Help You Age Less Today
by Sanjay Gupta (Hardcover - April 9, 2007)

15. The Essential Guide to Aging in the Twenty-first Century: Mind, Body, and Behavior
by Donald H. Kausler, Barry C. Kausler, and Jill A. Krupsaw (Paperback - April 9, 2007)

16. The 10-Minute Rejuvenation Plan: T5T: The Revolutionary Exercise Program That Restores Your Body and Mind
by Carolinda Witt (Paperback - April 3, 2007)

17. 2007-2008 Geriatrics At Your Fingertips
by David Rueben (Paperback - April 1, 2007)

18. 8 Powerful Secrets to Anti-Aging
by Dr. Paul Ling Tai (Hardcover - April 1, 2007)

19. Ageing in India: Socio-Economic and Health Dimensions
by Moneer Alam (Hardcover - April 1, 2007)

20. Alzheimer's: Where Do We Go from Here?
by Lisa W Smith (Hardcover - April 1, 2007)

21. Senescence Processes in Plants (Annual Plant Reviews)
by Susheng Gan, Marie-Jeanne Carp, Jen-Chih Chen, and Paul Dijkwel (Hardcover - April 1, 2007) - Illustrated

The same list is repeated below in enhanced version with book images added:

-----------------

Enhanced List with Book Images Provided

1.
Adult Development and Aging by Bert Hayslip, Julie Hicks-Patrick, and Paul E. Panek (Hardcover - April 30, 2007)

2.
Geriatric Rheumatology, An Issue of Rheumatic Disease Clinics (The Clinics: Internal Medicine) by Arthur F. Kavanaugh (Hardcover - April 30, 2007)

3.
Fostering Social Work Gerontology Competence: A Collection of Papers from the First National Gerontological Social Work Conference by Catherine J., Ph.D. Tompkins and Anita L., Ph.D. Rosen (Paperback - April 30, 2007)

4.
Social Care Challenges for the Ageing in Asia by Raymond Ngan and S. Vasoo (Paperback - April 30, 2007)

5.
Dementia: Metamorphosis in Care by Claire Biernacki (Paperback - April 27, 2007)

6.
Getting Started in A Financially Secure Retirement (Getting Started In.....) by Henry K. Hebeler (Paperback - April 27, 2007)

7.
Handbook of Gerontology: Evidence-Based Approaches to Theory, Practice, and Policy by James A. Blackburn and Catherine N. Dulmus (Hardcover - April 20, 2007)

8.
Brain Aging: Models, Methods, and Mechanisms (Frontiers in Neuroscience) by David R. Riddle (Hardcover - April 19, 2007)

9.
Neurobiology of Epilepsy and Aging, Volume 81 (International Review of Neurobiology.) by R. Eugene Ramsay, James C. Cloyd, Kevin M. Kelly, and Ilo E. Leppik (Hardcover - April 16, 2007)

10.
Healthy Aging & Longevity Third International Conference (Annals of the New York Academy of Sciences) by Weller Noah J (Paperback - April 15, 2007)

11.
Encyclopedia of Health and Aging by Kyriakos S. Markides (Hardcover - April 13, 2007)

12.
Assisted Dying and Legal Change by Penney Lewis (Hardcover - April 12, 2007)

13.
Intersections of Aging: Readings in Social Gerontology by Jon Hendricks, Elizabeth W. Markson, and Lisa A. Hollis-Sawyer (Paperback - April 10, 2007)

14.
Chasing Life: New Discoveries in the Search for Immortality to Help You Age Less Today by Sanjay Gupta (Hardcover - April 9, 2007)

15.
The Essential Guide to Aging in the Twenty-first Century: Mind, Body, and Behavior by Donald H. Kausler, Barry C. Kausler, and Jill A. Krupsaw (Paperback - April 9, 2007)

16.
The 10-Minute Rejuvenation Plan: T5T: The Revolutionary Exercise Program That Restores Your Body and Mind by Carolinda Witt (Paperback - April 3, 2007)

17.
2007-2008 Geriatrics At Your Fingertips by David Rueben (Paperback - April 1, 2007)

18.
8 Powerful Secrets to Anti-Aging by Dr. Paul Ling Tai (Hardcover - April 1, 2007)

19.
Ageing in India: Socio-Economic and Health Dimensions by Moneer Alam (Hardcover - April 1, 2007)

20.
Alzheimer's: Where Do We Go from Here? by Lisa W Smith (Hardcover - April 1, 2007)

21.
Senescence Processes in Plants (Annual Plant Reviews) by Susheng Gan, Marie-Jeanne Carp, Jen-Chih Chen, and Paul Dijkwel (Hardcover - April 1, 2007) - Illustrated

If you do know some new books that should be added to this list, please feel free to add them here!

Key words:
New books, aging, ageing, longevity, gerontology, gerontological, geriatrics, geriatric, senescence, anti-aging, rejuvenation, life-extension, immortality

Home:
Longevity Science Blog
and
Longevity Science: New Books for May 2007

Books on Aging

2007-04-10T20:11:00.000-07:00

Homosexuality and Fraternal Birth Order

2007-04-10T11:05:00.000-07:00

This is new story in the New York Times is really interesting:

Pas de Deux of Sexuality Is Written in the Genes
THE NEW YORK TIMES
By NICHOLAS WADE
Published: April 10, 2007
http://www.nytimes.com/2007/04/10/health/10gene.html?pagewanted=2&amp;amp;amp;amp;amp;amp;amp;amp;amp;_r=1&th&emc=th

A somewhat more straightforward clue to the origin of homosexuality is the fraternal birth order effect. Two Canadian researchers, Ray Blanchard and Anthony F. Bogaert, have shown that having older brothers substantially increases the chances that a man will be gay. Older sisters don’t count, nor does it matter whether the brothers are in the house when the boy is reared.

The finding suggests that male homosexuality in these cases is caused by some event in the womb, such as “a maternal immune response to succeeding male pregnancies,” Dr. Bogaert wrote last year in the Proceedings of the National Academy of Sciences. Antimale antibodies could perhaps interfere with the usual masculinization of the brain that occurs before birth, though no such antibodies have yet been detected.

The fraternal birth order effect is quite substantial. Some 15 percent of gay men can attribute their homosexuality to it, based on the assumption that 1 percent to 4 percent of men are gay, and each additional older brother increases the odds of same-sex attraction by 33 percent.

The effect supports the idea that the levels of circulating testosterone before birth are critical in determining sexual orientation. But testosterone in the fetus cannot be measured, and as adults, gay and straight men have the same levels of the hormone, giving no clue to prenatal exposure. So the hypothesis, though plausible, has not been proved.

It may be interesting to look on the last-born sons in large families composed mostly of sons, to see what is their reproductive success. It should decrease as the number of older brothers increases, controlling for the sibship size. Any predictions about their health and longevity?

It may be interesting to test whether men with older brothers live shorter lives or not.

By the way, here is a link to original study:

1: Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10771-4. Epub 2006 Jun 28.

Links

Comment in:: Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10531-2.

Biological versus nonbiological older brothers and men's sexual orientation.

Bogaert AF.

Department of Community Health Sciences, Brock University, St. Catharines, ON, Canada. tbogaert@brocku.ca

The most consistent biodemographic correlate of sexual orientation in men is the number of older brothers (fraternal birth order). The mechanism underlying this effect remains unknown. In this article, I provide a direct test pitting prenatal against postnatal (e.g., social/rearing) mechanisms. Four samples of homosexual and heterosexual men (total n = 944), including one sample of men raised in nonbiological and blended families (e.g., raised with half- or step-siblings or as adoptees) were studied. Only biological older brothers, and not any other sibling characteristic, including nonbiological older brothers, predicted men's sexual orientation, regardless of the amount of time reared with these siblings. These results strongly suggest a prenatal origin to the fraternal birth-order effect.

PMID: 16807297 [PubMed - indexed for MEDLINE]

See also:

Conundrum: The Evolution of Homosexuality
by N. J. Peters, Authorhouse - February 28, 2006

The Puzzle: Exploring the Evolutionary Puzzle of Male Homosexuality
by Louis Arthur Berman, Godot Press, 2003

New Books

2007-04-09T22:27:00.002-07:00

New Books on Aging and Longevity Studies.
You are most welcome to add new books here yourself if you do know some new interesting books!

Greetings,

This is a place for continuously updated list of new interesting books on aging and longevity.

Consider this as a starter, and please feel free to add new books here!
(Please do not forget to mention the book ISBN number, if you know it!)

New Books and Book Chapters:

• Ageing: The Paradox of Life
by Robin Holliday (Hardcover - Mar 2007)

• Ageing Well: Nutrition, Health, and Social Interventions
by Alan Dangour, Emily M. D. Grundy, and Astrid Fletcher - Mar 1, 2007

• Aging of the Genome: The Dual Role of DNA in Life and Death
by Jan Vijg

• Aging and Disability: Crossing Network Lines
by Michelle Putnam (Editor) - Feb 28, 2007

• The Art of Aging:
A Doctor's Prescription for Well-Being
by Sherwin B. Nuland - February 27, 2007

This popular book is discussed here.

• How to Live Forever or Die Trying
by Bryan Appleyard - January 22, 2007

This popular book discussed here

• Statistical and Process Models for Cognitive Neuroscience and Aging (Notre Dame Series on Quantitative Methodology)
by Michael J. Wenger and Christof Schuster (Editors) - Jan 15, 2007

• Aging Research: A Look at Some of the Scientific Evidence on Aging
by Harold Massie Ph.D. (Paperback - Jan 10, 2007)

• Health Aspects of Aging: The Experience of Growing Old
by Gari Lesnoff-Caravaglia (Hardcover - Jan 2007)

• Mechanisms of Dietary Restriction in Aging and Disease (Interdisciplinary Topics in Gerontology)
by C. V. Mobbs, K. Yen, and P. R. Hof

• Book Chapter "Cytokine Polymorphisms and Longevity"
By Irene Maeve Rea, Giuseppina Candore, Luca Cavallone, Fabiola Olivieri, Maurizio Cardelli, Claudio Franceschi, Giuseppina Colonna-Romano,Domenico Lio, Owen A. Ross and Calogero Caruso
In: Cytokine Gene Polymorphisms in Multifactorial Conditions
by Koen Vandenbroeck (Editor)

• Book chapter "Anti-Aging Medicine and Science: Social Implications" by Robert H. Binstock, Jennifer R. Fishman, and Thomas E. Johnson
In: Handbook of Aging and the Social Sciences, Sixth Edition (Handbook of Aging) by Robert H. Binstock (Editor), Linda K. George (Editor)

• Book chapter "Mechanisms of Aging"
by Leng SX and Fedarko NS.
In: Geriatric Anesthesia
by Frederick E. Sieber

• Human Longevity, Individual Life Duration, and the Growth of the Oldest-Old Population (International Studies in Population)
by Jean-Marie Robine (Editor), Eileen M. Crimmins (Editor), Shiro Horiuchi (Editor), Yi Zeng (Editor)

Note a chapter "Patterns in mammalian aging: demography and evolution" by SN Austad there.

• Book chapter "The Mouse in Aging Research"
by Flurkey K, Currer JM, Harrison DE.
In: The Mouse in Biomedical Research, Volume 1-4, Second Edition (American College of Laboratory Animal Medicine)
by James G. Fox, Stephen Barthold, Muriel Davisson, and Christian E. Newcomer

• Longevity Health Sciences: The Phoenix Conference (Annals of the New York Academy of Sciences)
by Richard G. Cutler, Stromboli Conference on Aging And Cancer, Walter Pierpaoli, and Phonenix Conference on Longevity Health

• Longer Life and Healthy Aging (International Studies in Population) by Y. Zeng (Author), Yi Zeng (Editor), Eileen M. Crimmins (Editor)

Note a chapter there: "Aging without dementia"
by Barberger-Gateau P, et al.,

• Biological Aging:
Methods And Protocols
(Methods in Molecular Biology (Clifton, N.J.), V. 371.)
by Trygve O. Tollefsbol (Editor)

• Aging Nation:
The Economics and Politics of Growing Older in America
by James H. Schulz, Robert H. Binstock

• New Dynamics in Old Age:
Individual, Environmental And Societal Perspectives
(Society and Aging Series)
by Hans-Werner, Ph.D. Wahl (Editor), Clemens Tesch-roemer (Editor), Andreas Hoff (Editor)

• The Evolution of Death:
Why We Are Living Longer
(Suny Series in Philosophy and Biology)
by Stanley Shostak

• Biology, Sociology, Geology by Computational Physicists,
Volume 1 (Monograph Series on Nonlinear Science and Complexity)
by Dietrich Stauffer et al.

This book includes discussion of biological aging, human mortality and longevity.

• Extending the Lifespan:
Biotechnical, Gerontological, and Social Problems
by Klaus Sames (Editor), Sebastian Sethe (Editor), Alexandra Stolzing (Editor)

Contributions by:
Vladimir N. ANISIMOV, Alexander BUERKLE, Gerald DeHAAN, Gerhard HOFECKER, Michael S. JAZWINSKI, Frieder KELLER, Valery N. KHABASHESKU, Tilmann KLEINE, Rosemarie MARTIN, Christoph MEISSNER, Ann-Kathrin MEYER, Will W.MINUTH, Gerald M NCH, Khachik MURADIAN, William O. OGLE, Klaus P SCHEL, Wolfgang von RENTELN-KRUSE, Volker RICHTER, Ramon RISCO, George S.ROTH, Antonio RUIZ-TORRES, Kenneth B. STOREY, Stefan THALHAMMER, Peter VISCHER, Jan WOJNAR, Bartosz WOZNIAK

• Biology of Aging: Observations and Principles
by Robert Arking

Textbook, third edition

• Aging: Concepts and Controversies
by Harry R. Moody

• Enduring Questions in Gerontology
by Debra J. Sheets, Dana Burr Bradley, and Jon Hendricks

Note a chapter "A biologist’s perspective: whence come we, where are we, whither go we?" by SN Austad there.

• The Evolution of Aging
How New Theories Will Change the Future of Medicine
by Theodore C. Goldsmith - October 17, 2006

This popular book is discussed here

• The Truth About Aging: Can We Really Live Longer and Healthier? (Full Spectrum Information Library Series)
by George Roth

• What Books People Read?
Somewhat disturbing list of best-selling books on aging and longevity

Upcoming:

• Austad, SN & Finch, CE (2007) The evolutionary context of human aging and degenerative disease. in S.C. Stearns & J.C. Koella (Eds). Evolution in Health and Disease, 2nd Edition. Oxford University Press, Oxford, UK (in press).

• The Biology of Human Longevity:
Inflammation, Nutrition, and Aging in the Evolution of Lifespans
by Caleb E. Finch (Hardcover - Jun 26, 2007)

• Forever and Ever
by Dan A. Baker - April 1, 2007

This novel (not scientific book) is discussed here

Have Questions? Comments? New Books to Suggest?
Post them below!

Key words:
New books, Ageing, Aging, Longevity, Life-extension, Genome, DNA, Death, Disability, Growing Old, Dietary Restriction, Disease, Gerontology, Anti-Aging Medicine, Life Duration, Oldest-Old, Longer Life, Healthy Aging, Growing Older, Old Age, Evolution of Death, Lifespan, Evolution of Aging, Human Longevity.